Results 11 to 20 of about 362,065 (266)

Targeted Diphtheria Toxin-Based Therapy: A Review Article. [PDF]

Front Microbiol, 2019
Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Shafiee F, Aucoin MG, Jahanian-Najafabadi A.   +2 more
europepmc   +2 more sources

THE PRODUCTION OF DIPHTHERIA TOXIN [PDF]

Journal of Experimental Medicine, 1896
Toxin of sufficient strength to kill a 400-gramme guinea-pig in three days and a half in a dose of 0·cubic centimetre developed in suitable bouillon, contained in ordinary Erlenmeyer flasks, within a period of twenty-four hours. In such boullon the toxin reached its greatest strength in from four to seven days (0·005 cubic centimetre killing a 500 ...
W H, Park, A W, Williams
openaire   +3 more sources

Diphtheria Toxin

The Journal of Immunology, 1929
Abstract The preparation of diphtheria toxins from the time of its discovery by Behring has been repeatedly investigated with the development of many changes in its preparation, but it still presents many difficulties. The urgent need of strong potent toxins for the Ramon flocculation tests for titration of diphtheria antitoxins, and ...
O. R. Povitzky
openaire   +2 more sources

Production of IgY polyclonal antibody against diphtheria toxin and evaluation of its neutralization effect by Vero cell assay [PDF]

BMC Biotechnology, 2021
Background Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria.
Morteza Rezaeifard, Roya Solhi, Mohammad Mohammadi, Ebrahim Abbasi, Mahdi Aminian   +4 more
doaj   +2 more sources

Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain [PDF]

Toxins, 2020
Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin, Maithri M. Kashipathy, Alexander Kyrychenko, Kevin P. Battaile, Scott Lovell, Alexey S. Ladokhin   +5 more
doaj   +2 more sources

Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin. [PDF]

J Biomed Sci
Matsumoto D, Kubota K, Sato Y, Kato-Inui T, Nigorikawa K, Miyaoka Y, Nomura W.   +6 more
europepmc   +2 more sources

Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis [PDF]

Frontiers in Pharmacology
Many bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter human or animal cells and act as enzymes in their cytosol.
Joscha Borho, Merle Kögel, Amelie Eckert, Holger Barth   +3 more
doaj   +2 more sources

The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles. [PDF]

Pharmaceutics, 2022
Voltà-Durán E, Sánchez JM, Parladé E, Serna N, Vazquez E, Unzueta U, Villaverde A.   +6 more
europepmc   +3 more sources

Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma.

Dis Model Mech, 2021
Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K.   +5 more
europepmc   +2 more sources

Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. [PDF]

Cancers (Basel), 2020
Kamimura K, Yokoo T, Abe H, Sakai N, Nagoya T, Kobayashi Y, Ohtsuka M, Miura H, Sakamaki A, Kamimura H, Miyamura N, Nishina H, Terai S.   +12 more
europepmc   +3 more sources