Results 11 to 20 of about 89,499 (267)

Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold. [PDF]

Commun Biol, 2022
Sugiman-Marangos SN, Gill SK, Mansfield MJ, Orrell KE, Doxey AC, Melnyk RA.   +5 more
europepmc   +3 more sources

Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation. [PDF]

J Neuroinflammation, 2022
Bedolla A, Taranov A, Luo F, Wang J, Turcato F, Fugate EM, Greig NH, Lindquist DM, Crone SA, Goto J, Luo Y.   +10 more
europepmc   +3 more sources

Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma.

Dis Model Mech, 2021
Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K.   +5 more
europepmc   +2 more sources

Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. [PDF]

Cancers (Basel), 2020
Kamimura K, Yokoo T, Abe H, Sakai N, Nagoya T, Kobayashi Y, Ohtsuka M, Miura H, Sakamaki A, Kamimura H, Miyamura N, Nishina H, Terai S.   +12 more
europepmc   +3 more sources

BIOLOGICAL PROPERTIES AND MEDICAL APPLICATION OF DIPHTHERIA TOXIN DERIVATIVES [PDF]

Biotechnologia Acta, 2018
The aim of the review was to analyze the literature data related to the application of a variety of diphtheria toxin derivatives. Although studies of the diphtheria toxin interaction with sensitive and resistant mammalian cells have been held for a ...
Manoilov K.Y.
doaj   +1 more source

IMMUNOBIOLOGY OF DIPHTHERIA. RECENT APPROACHES FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF DISEASE [PDF]

Biotechnologia Acta, 2013
Diphtheria is a highly contagious life-threatening disease caused by the toxi genic strains of Corynebacterium diphtheria, which are transformed by a bacteriophage carrying the toxin gene.
D. V. Kolybo, A. A. Labyntsev, S. I. Romaniuk, A. A Kaberniuk, O. M. Oliinyk, N. V. Korotkevich, S. V. Komisarenko   +6 more
doaj   +1 more source

Assay of Diphtheria Vaccine Potency by Intradermal Challenge Test

Эпидемиология и вакцинопрофилактика, 2023
Relevance. Modern identifying potency (immunogenicity) of diphtheria toxoid tests are based on determining immunized animals resistance for administration challenge toxin or evaluation of protective antibodies level in serum.
E. I. Komarovskaya, О. V. Perelygyna
doaj   +1 more source

INTERACTION OF RECOMBINANT DIPHTHERIA TOXOIDS WITH CELLULAR RECEPTORS in vitro [PDF]

Biotechnologia Acta, 2016
The aim of the research was to compare in vitro characteristics of reception of the natural diphtheria toxin — DT and its nontoxic recombinant analogs — toxoids.
K. Yu. Manoilov, A. Ju. Labyntsev, N. V. Korotkevych, D. V. Kolibo, S. V. Komisarenko   +4 more
doaj   +1 more source

Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]

Osong Public Health and Research Perspectives, 2018
Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi, Jae Hoon Moon, Jae Ok Kim, Si Hyung Yoo, Hyeon Guk Kim, Jung-Hwan Kim, Tae Jun Park, Sung Soon Kim   +7 more
doaj   +1 more source

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +4 more sources