Results 11 to 20 of about 358,147 (271)
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Nature Communications, 2017 Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira +10 more
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The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells
Scientific Reports, 2017 Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be ...
Manuel Schuster +16 more
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Toxins, 2016 Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell +5 more
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THE PRODUCTION OF DIPHTHERIA TOXIN [PDF]
Journal of Experimental Medicine, 1896 Toxin of sufficient strength to kill a 400-gramme guinea-pig in three days and a half in a dose of 0·cubic centimetre developed in suitable bouillon, contained in ordinary Erlenmeyer flasks, within a period of twenty-four hours. In such boullon the toxin reached its greatest strength in from four to seven days (0·005 cubic centimetre killing a 500 ...
W H, Park, A W, Williams
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Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis. [PDF]
J Exp Med, 2023 This work demonstrates that diphtheria toxin is a potent trigger for the ZAKα-dependent ribotoxic stress response and the NLRP1 inflammasome in human skin cells. ZAKα inhibition is effective at limiting the skin damage caused by diphtheria toxin in vitro.
Robinson KS +13 more
europepmc +2 more sources
Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay. [PDF]
Vaccines (Basel), 2021 Background: The diphtheria toxoid antigen is a major component in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination.
De-Simone SG +5 more
europepmc +2 more sources
Journal of Immunology, 1929 The preparation of diphtheria toxins from the time of its discovery by Behring has been repeatedly investigated with the development of many changes in its preparation, but it still presents many difficulties.
Olga R. Povitzky
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Human antibodies neutralizing diphtheria toxin in vitro and in vivo. [PDF]
Sci Rep, 2020 Diphtheria is an infectious disease caused by Corynebacterium diphtheriae. The bacterium primarily infects the throat and upper airways and the produced diphtheria toxin (DT), which binds to the elongation factor 2 and blocks protein synthesis, can ...
Wenzel EV +9 more
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Targeted Diphtheria Toxin-Based Therapy: A Review Article. [PDF]
Front Microbiol, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Shafiee F +2 more
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Diphtheria Toxin-Antitoxin and Toxoid
American Journal of Public Health and the Nations Health, 1932 William H. Park, M. Carl Schroder
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