Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]
Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi+7 more
doaj +1 more source
SINGLE CHAIN VARIABLE FRAGMENTS OF ANTIBODIES AGAINST DIPHTHERIA TOXIN B-SUBUNIT ISOLATED FROM PHAGE DISPLAY HUMAN ANTIBODY LIBRARY [PDF]
Diphtheria toxin is an exoantigen of Corynebacterium diphtheriae that inhibits protein synthesis and kills sensitive cells. The aim of this study was to obtain human recombinant single-chain variable fragment (scFv) antibodies against receptor-binding B ...
Oliinyk O. S.+3 more
doaj +1 more source
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent+32 more
core +4 more sources
Diphtheria: A case series from West Maharashtra, India
Diphtheria is an acute infectious toxin mediated disease caused by Corynebacterium diphtheriae. Effective vaccination has decreased the incidence of disease globally. However, despite of a full-fledged Universal Immunization Programme, the cases
Snehal Patil+3 more
doaj +1 more source
Respiratory illness caused by Corynebacterium diphtheriae and C. ulcerans, and use of diphtheria anti-toxin in the United States, 1996-2018. BACKGROUND Respiratory diphtheria is a toxin-mediated disease caused by Corynebacterium diphtheriae. Diphtheria-
John O. Otshudiema+5 more
semanticscholar +1 more source
The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement [PDF]
Lysosomotropic amines, such as ammonium chloride, are known to protect cells from the cytotoxic effects of diphtheria toxin. These drugs are believed to inhibit the transport of the toxin from a receptor at the cell exterior into the cytoplasm where a ...
Draper, Rockford K., Simon, Melvin I.
core +2 more sources
Genetic characterization of diphtheria tox B to evaluate vaccine efficacy in Indonesia
Background and Objectives: Blocking the attachment of diphtheria toxins to host cells through the intact receptor binding site (tox B) was the initial mechanism of action of the diphtheria vaccine.
Yeva Rosana+2 more
doaj +1 more source
Coexistence of Competing Microbial Strains under Twofold Environmental Variability and Demographic Fluctuations [PDF]
Microbial populations generally evolve in volatile environments, under conditions fluctuating between harsh and mild, e.g. as the result of sudden changes in toxin concentration or nutrient abundance. Environmental variability thus shapes the long-time population dynamics, notably by influencing the ability of different strains of microorganisms to ...
arxiv +1 more source
Diphtheritic myocarditis: A case series and review of literature
Myocarditis in patients with diphtheria is a toxin-mediated complication that sets in after one week of onset of respiratory illness. Early administration of antidiphtheritic serum in patients with clinical diphtheria before the onset of myocarditis is ...
Sonali Singh, Nitin Gupta, Pallavi Saple
doaj +1 more source
Proteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae [PDF]
Introduced for mass immunization in the 1920s, vaccines against diphtheria are among the oldest and safest vaccines known. The basic principle of their production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which ...
Burkovski, Andreas+11 more
core +1 more source