Results 31 to 40 of about 358,147 (271)

Diphtheria toxin time-resolved absorption and resonance ft-ir and raman biospectroscopy and density functional theory (dft) investigation of vibronic-mode coupling structure in vibrational spectra analysis: a spectroscopic study on an anti-cancer drug

Clinical Case Studies and Reports, 2019
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source

Beyond diphtheria toxin: cytotoxic proteins of Corynebacterium ulcerans and Corynebacterium diphtheriae.

Microbiology, 2019
Diphtheria toxin is one of the best investigated bacterial toxins and the major virulence factor of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains.
Dulanthi Weerasekera, J. Möller, M. Kraner, Camila Azevedo Antunes, A. Mattos-Guaraldi, A. Burkovski   +5 more
semanticscholar   +1 more source

Kinetics of Diphtheria Toxin Formation [PDF]

Journal of General Microbiology, 1962
SUMMARY: Studies on the kinetics of diphtheria toxin formation in iron-free culture media by variants of the PW no. 8 strain of Corynebacterium diphtheriae labelled with 14C-phenylalanine or 35S-methionine, showed that the toxin protein was synthesized de novo from amino acids by growing organisms.
Alwin M. Pappenheimer, Masahiko Yoneda, Pauline A. Miller   +2 more
openaire   +3 more sources

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Identification of a diphtheria toxin‐like gene family beyond the Corynebacterium genus

FEBS Letters, 2018
Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of the most potent protein toxins known; however, it has an unclear evolutionary history.
Michael J. Mansfield, S. Sugiman-Marangos, R. Melnyk, A. Doxey   +3 more
semanticscholar   +1 more source

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein that depletes Tregs, was approved
Laurene S Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, S. Parveen, C. K. Bullen, G. Patrick, R. Harrison, J. Murphy, D. Pardoll, W. Bishai   +12 more
semanticscholar   +1 more source

Transmission of toxigenic Corynebacterium ulcerans infection with airway obstruction from cats to a human

Acute Medicine & Surgery, 2021
Background Infections caused by Corynebacterium ulcerans, a zoonotic pathogen, have been reported worldwide. This microorganism is known to produce the diphtheria toxin and cause diphtheria‐like illness.
Koji Wake, Jin Kikuchi, Masatoshi Uchida, Masato Nemoto, Yoshiyuki Kaji, Tatsuya Yokoyama, Hiromichi Suzuki, Atsuhito Fukushima, Akihiko Yamamoto, Masaaki Iwaki, Kazuyuki Ono   +10 more
doaj   +1 more source

The Aftermath of Flood Crises- Diphtheria Outbreak in Sindh [PDF]

Liaquat National Journal of Primary Care, 2023
The recent floods in Pakistan have not only resulted in greater than 1290 deaths and 12500 flood-related injuries but also thousands of cases of communicable and non-communicable diseases [1].
Syed Bilal Hashmi, Laraib Malik
doaj   +1 more source

Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice

Journal of Neuroscience, 2016
Cochlear hair cells (HCs), the sensory cells that respond to sound, do not regenerate after damage in adult mammals, and their loss is a major cause of deafness.
Lingxiang Hu, Jingrong Lu, Chiang Hao, Hao Wu, A. Edge, Fuxin Shi   +5 more
semanticscholar   +1 more source