Results 31 to 40 of about 335,512 (263)
Retrograde transport pathways utilised by viruses and protein toxins [PDF]
, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Easton, A. J. (Andrew J.) +4 more
core +2 more sources
Clinical Case Studies and Reports, 2019 Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari +2 more
semanticscholar +1 more source
Microbe profile : Corynebacterium diphtheriae - an old foe always ready to seize opportunity [PDF]
, 2018 Diphtheria AB toxin mode of action. The diphtheria AB exotoxin consists of two polypeptide chains - A and B which are linked by a disulfide bridge. The B chain binds to the heparin-binding epidermal growth factor precursor on eukaryotic cells and is ...
Hoskisson, Paul A.
core +1 more source
Toxin-mediated competition in weakly motile bacteria [PDF]
2019, J. Theor. Biol. 480 , 205-217, 2019 Many bacterial species produce toxins that inhibit their competitors. We model this phenomenon by extending classic two-species Lotka-Volterra competition in one spatial dimension to incorporate toxin production by one species. Considering solutions comprising two adjacent single-species colonies, we show how the toxin inhibits the susceptible species ...
arxiv +1 more source
Using Multiscale Molecular Dynamics Simulations to Obtain Insights into Pore Forming Toxin Mechanisms [PDF]
Methods in Enzymology (Chapter Sixteen), 2021, 2020 Pore forming toxins (PFTs) are virulent proteins released by several species, including many strains of bacteria, to attack and kill host cells. In this article, we focus on the utility of molecular dynamics (MD) simulations and the molecular insights gleaned from these techniques on the pore forming pathways of PFTs.
arxiv +1 more source
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
, 1994 Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Akiyama +182 more
core +1 more source
Identification of a diphtheria toxin‐like gene family beyond the Corynebacterium genus
FEBS Letters, 2018 Diphtheria toxin (DT), produced by Corynebacterium diphtheria, is the causative agent of diphtheria and one of the most potent protein toxins known; however, it has an unclear evolutionary history.
Michael J. Mansfield +3 more
semanticscholar +1 more source
Population genomics and antimicrobial resistance in Corynebacterium diphtheriae
Genome Medicine, 2020 Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart +12 more
doaj +1 more source
Iranian Journal of Microbiology, 2020 Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana +4 more
doaj +1 more source
Outbreak with clonally related isolates of Corynebacterium ulcerans in a group of water rats [PDF]
, 2015 BACKGROUND: The zoonotic bacterium Corynebacterium ulcerans may be pathogenic both in humans and animals: toxigenic strains can cause diphtheria or diphtheria-like disease in humans via diphtheria toxin, while strains producing the dermonecrotic exotoxin
Althoff, Gisa +11 more
core +2 more sources