Results 31 to 40 of about 89,499 (267)

Studies on the denaturation of antibody: II. The effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea [PDF]

, 1945
The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied.
Wright, George G.
core   +1 more source

Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Toxins, 2016
Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell, Ann-Katrin Mittler, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth   +5 more
doaj   +1 more source

Outbreak with clonally related isolates of Corynebacterium ulcerans in a group of water rats [PDF]

, 2015
BACKGROUND: The zoonotic bacterium Corynebacterium ulcerans may be pathogenic both in humans and animals: toxigenic strains can cause diphtheria or diphtheria-like disease in humans via diphtheria toxin, while strains producing the dermonecrotic exotoxin
Althoff, Gisa, Contzen, Matthias, Eisenberg, Tobias, Ewers, Christa, Geiger, Christina, Konrad, Regina, Margos, Gabriele, Mauder, Norman, Rau, Jörg, Schauerte, Nicole, Schlez, Karen, Sing, Andreas   +11 more
core   +2 more sources

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

Genome Medicine, 2020
Background Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population ...
Melanie Hennart, Leonardo G. Panunzi, Carla Rodrigues, Quentin Gaday, Sarah L. Baines, Marina Barros-Pinkelnig, Annick Carmi-Leroy, Melody Dazas, Anne Marie Wehenkel, Xavier Didelot, Julie Toubiana, Edgar Badell, Sylvain Brisse   +12 more
doaj   +1 more source

Detection of toxin-producing Corynebacterium diphtheriae from throat swabs of diphtheria patients using duplex real-time PCR

Iranian Journal of Microbiology, 2020
Background and Objectives: Diphtheria is a potentially fatal disease caused by toxigenic bacterial infection, particularly from Corynebacterium diphtheriae (C. diphtheriae). Isolation of C.
Yeva Rosana, Luh Inta Prilandari, Ruhsyahadati Ajisman, Teguh Sarry Hartono, Andi Yasmon   +4 more
doaj   +1 more source

Severe pertussis infection in infants less than 6 months of age: clinical manifestations and molecular characterization [PDF]

, 2017
We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2
Buttinelli, Gabriele, Carsetti, Rita, Concato, Carlo, Di Mattia, Greta, Fedele, Giorgio, Gesualdo, Francesco, Midulla, Fabio, Nicolai, Ambra, Stefanelli, Paola, the Pertussis Study Group,, Tozzi, Alberto E., Vacca, Paola, Villani, Alberto   +12 more
core   +1 more source

Transmission of toxigenic Corynebacterium ulcerans infection with airway obstruction from cats to a human

Acute Medicine & Surgery, 2021
Background Infections caused by Corynebacterium ulcerans, a zoonotic pathogen, have been reported worldwide. This microorganism is known to produce the diphtheria toxin and cause diphtheria‐like illness.
Koji Wake, Jin Kikuchi, Masatoshi Uchida, Masato Nemoto, Yoshiyuki Kaji, Tatsuya Yokoyama, Hiromichi Suzuki, Atsuhito Fukushima, Akihiko Yamamoto, Masaaki Iwaki, Kazuyuki Ono   +10 more
doaj   +1 more source

Does counseling increase sustained benefit of HAART among prison inmates after release to the community? [PDF]

, 2005
The lack of sustained effectiveness of HAART after release to the community of HIV-infected inmates treated in prison was well demonstrated by Springer et al. in a recent article.
Babudieri, Sergio, Maida, Ivana Rita, Pintus, Antonio, Rezza, Giovanni, Starnini, Giulio   +4 more
core   +1 more source