Results 41 to 50 of about 358,147 (271)
Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.
JCI Insight, 2016 Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in
J. Gardenier +11 more
semanticscholar +1 more source
Novelty in Biomedicine, 2018 Background: Targeted cancer therapies have played a great role in the treatment of malignant tumors, in the recent years. Among these therapies, targeted toxin therapies such as immunotoxins, has improved the patient’s survival rate by minimizing the ...
Sahel Amoozadeh +4 more
doaj +1 more source
The Action of Diphtheria Toxin on Mice [PDF]
Journal of Hygiene, 1922 1. For the particular toxin tested, the intravenous m.l.d. for mice was 60 times and the intramuscular m.l.d. for mice 100 times, the guinea-pig sub cutaneous m.l.d.2. Antitoxin has the same neutralising power for toxin in mice as in guinea-pigs.
K. Allen, A. T. Glenny
openaire +3 more sources
Conformational Switching of the Diphtheria Toxin T-Domain [PDF]
Biophysical Journal, 2010 The diphtheria toxin T domain translocates the catalytic C domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of the T domain, we have used site-directed mutagenesis coupled with spectroscopic and physiological assays.
R. John Collier +7 more
openaire +4 more sources
Imported Toxin-Producing Cutaneous Diphtheria — Minnesota, Washington, and New Mexico, 2015–2018
MMWR. Morbidity and mortality weekly report, 2019 From September 2015 to March 2018, CDC confirmed four cases of cutaneous diphtheria caused by toxin-producing Corynebacterium diphtheriae in patients from Minnesota (two), Washington (one), and New Mexico (one).
J. Griffith +10 more
semanticscholar +1 more source
Toxins, 2015 The cholix toxin gene (chxA) was first identified in V. cholerae strains in 2007, and the protein was identified by bioinformatics analysis in 2008. It was identified as the third member of the diphtheria toxin group of mono-ADP-ribosyltransferase toxins
Miguel R. Lugo, A. Rod Merrill
doaj +1 more source
Data in Brief, 2022 Corynebacterium diphtheriae (C. diphtheriae) is the causative agent of diphtheria. The main virulence factor of C. diphtheriae is diphtheria toxin, which is encoded by the tox gene and regulated by the dtxR gene.
Vivi Setiawaty +11 more
doaj +1 more source
SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIC-CO-GLYCOLIC)ACID MICROPARTICLES LOADED BY DIPHTHERIA TOXOID [PDF]
Biotechnologia Acta, 2018 The aim of the study was to synthesize poly(D,L-lactide-co-glycolide) particles — PLGA and obtain their complexes with a non-toxic diphtheria toxin recombinant fragment subunit B fused with enhanced green fluorescent protein EGFP-SubB; to characterize ...
T. O. Chudina +2 more
doaj +1 more source
Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development
Toxins, 2015 Background: Targeted toxins require multiple treatments and therefore must be deimmunized. We report a method of protein deimmunization based on the point mutation of highly hydrophilic R, K, D, E, and Q amino acids on the molecular surface of truncated ...
J. Schmohl +3 more
semanticscholar +1 more source
Human Vaccines & Immunotherapeutics, 2017 There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics.
Heidi L. Smith +5 more
doaj +1 more source