Results 51 to 60 of about 28,936 (237)

Coexistence of competing metabolic pathways in well-mixed populations [PDF]

Phys. Rev. E 93, 052401 (2016), 2016
Understanding why strains with different metabolic pathways that compete for a single limiting resource coexist is a challenging issue within a theoretical perspective. Previous investigations rely on mechanisms such as group or spatial structuring to achieve a stable coexistence between competing metabolic strategies.
arxiv   +1 more source

Matrix Viscoelasticity Orchestrates Osteogenesis via Mechanotransduction Mediated Metabolic Switch in Macrophages

Advanced Healthcare Materials, EarlyView.
Fast‐relaxation viscoelastic hydrogel triggers a metabolic shift in macrophages, favoring oxidative phosphorylation (OXPHOS) over glycolysis via vasodilator‐stimulated phosphoprotein (VASP) / hypoxia‐inducible factor 1 alpha (HIF1α) signaling meditated mechanotransdution, thereby enhancing their capacity to recruit mesenchymal stem cells (MSCs) and ...
Dihao Tao, Hanzhe Wang, Shiping Chang, Jiayu Cheng, Ningning Da, Li Zhang, Jianhua Yang, Wenzhe Wang, Feng Xu, Bei Li   +9 more
wiley   +1 more source

Observations on the Structure of Diphtheria Toxin

Journal of Biological Chemistry, 1971
Diphtheria toxin is synthesized as a single polypeptide chain with a molecular weight of about 62,000. After being secreted it may be partially digested by proteolytic enzymes released from the bacterial cells into the culture medium and purified preparations of toxin usually contain some of the proteolytic breakdown products.
Linda L. Dinius, D. Michael Gill
openaire   +3 more sources

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Fluid flow enhances the effectiveness of toxin export by aquatic microorganisms: a first-passage perspective on microvilli and the concentration boundary layer [PDF]

, 2014
A central challenge for organisms during development is determining a means to efficiently export toxic molecules from inside the developing embryo. For aquatic microorganisms, the strategies employed should be robust with respect to the variable ocean environment and limit the chances that exported toxins are reabsorbed.
arxiv   +1 more source

Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia

Emerging Infectious Diseases, 2017
By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria.
Christine J. Doyle, Adam Mazins, Rikki M.A. Graham, Ning-Xia Fang, Helen V. Smith, Amy V. Jennison   +5 more
doaj   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

A Perturbative Approach to the Analysis of Many-Compartment Models Characterized by the Presence of Waning Immunity [PDF]

arXiv, 2021
The waning of immunity after recovery or vaccination is a major factor accounting for the severity and prolonged duration of an array of epidemics, ranging from COVID-19 to diphtheria and pertussis. To study the effectiveness of different immunity level-based vaccination schemes in mitigating the impact of waning immunity, we construct epidemiological ...
arxiv  

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

ESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source

Clinical Characteristics of Corynebacterium ulcerans Infection, Japan

Emerging Infectious Diseases, 2023
Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C.
Akihiko Yamamoto, Toru Hifumi, Manabu Ato, Masaaki Iwaki, Mitsutoshi Senoh, Akio Hatanaka, Shinichi Nureki, Yoshihiro Noguchi, Tomoko Hirose, Yukihiro Yoshimura, Takaaki Urakawa, Shiro Hori, Hiroto Nakada, Tomomasa Terada, Tomoko Ishifuji, Hisayo Matsuyama, Takahiro Kinebuchi, Atsuhito Fukushima, Koji Wake, Ken Otsuji, Takeru Endo, Hirokazu Toyoshima, Ikkoh Yasuda, Takeshi Tanaka, Naoki Takahashi, Kensaku Okada, Toshimasa Hayashi, Taizo Kusano, Minami Koriyama, Norio Otani, Motohide Takahashi   +30 more
doaj   +1 more source