Results 51 to 60 of about 20,093 (170)
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Modeling sRNA-regulated Plasmid Maintenance [PDF]
, 2016 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid. Key to their function is the tight regulation of expression of a protein toxin by an sRNA antitoxin.
arxiv +1 more source
Chemical warfare and survival strategies in bacterial range expansions [PDF]
J. R. Soc. Interface 11, 20140172 (2014), 2014 Dispersal of species is a fundamental ecological process in the evolution and maintenance of biodiversity. Limited control over ecological parameters has hindered progress in understanding of what enables species to colonise new area, as well as the importance of inter-species interactions.
arxiv +1 more source
Conformational Switching of the Diphtheria Toxin T-Domain [PDF]
Biophysical Journal, 2010 The diphtheria toxin T domain translocates the catalytic C domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of the T domain, we have used site-directed mutagenesis coupled with spectroscopic and physiological assays.
R. John Collier +7 more
openaire +4 more sources
The Action of Diphtheria Toxin on Mice [PDF]
Journal of Hygiene, 1922 1. For the particular toxin tested, the intravenous m.l.d. for mice was 60 times and the intramuscular m.l.d. for mice 100 times, the guinea-pig sub cutaneous m.l.d.2. Antitoxin has the same neutralising power for toxin in mice as in guinea-pigs.
K. Allen, A. T. Glenny
openaire +3 more sources
Toxins, 2015 The cholix toxin gene (chxA) was first identified in V. cholerae strains in 2007, and the protein was identified by bioinformatics analysis in 2008. It was identified as the third member of the diphtheria toxin group of mono-ADP-ribosyltransferase toxins
Miguel R. Lugo, A. Rod Merrill
doaj +1 more source
SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIC-CO-GLYCOLIC)ACID MICROPARTICLES LOADED BY DIPHTHERIA TOXOID [PDF]
Biotechnologia Acta, 2018 The aim of the study was to synthesize poly(D,L-lactide-co-glycolide) particles — PLGA and obtain their complexes with a non-toxic diphtheria toxin recombinant fragment subunit B fused with enhanced green fluorescent protein EGFP-SubB; to characterize ...
T. O. Chudina +2 more
doaj +1 more source
Advanced Materials, EarlyView.This study presents a polyanhydride‐based delivery platform for single‐injection, self‐boosting vaccines. The system enables programmable, pulsatile release of diphtheria toxoid with high antigen recovery and is guided by machine learning for tunability. In vivo results show immune responses comparable to multi‐dose regimens, highlighting its potential
Linzixuan Zhang +17 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2017 There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics.
Heidi L. Smith +5 more
doaj +1 more source
Toxins, 2020 Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin +5 more
doaj +1 more source