Results 61 to 70 of about 362,065 (266)

Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island

Genome Medicine, 2014
BackgroundToxigenic Corynebacterium ulcerans can cause a diphtheria-like illness in humans and have been found in domestic animals, which were suspected to serve as reservoirs for a zoonotic transmission. Additionally, toxigenic C. ulcerans were reported
D. Meinel, G. Margos, R. Konrad, S. Krebs, H. Blum, A. Sing   +5 more
semanticscholar   +1 more source

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

Methods of control diphtheria vaccine safety

Annals of Mechnikov's Institute, 2020
Vaccination success depends not only on the timely coverage of threatened contingents, but also on the quality of vaccines. Every day, the requirements for security guarantees vaccines and their use guarantees of security increases.
Ye Isayenko, Ye Babych, I Yelyseyeva, L Zhdamarova, V Belozersky, S Kolpak   +5 more
doaj  

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

Brain Pathology, EarlyView.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki, Tomotsugu Kurauchi, Akitoshi Hara, Nobutoshi Esaki, Shinji Mii, Ryota Ando, Akihiro Sakai, Kuniaki Tanahashi, Fumiharu Ohka, Ryuta Saito, Atsushi Natsume, Yuki Hattori, Takaki Miyata, Atsushi Enomoto   +13 more
wiley   +1 more source

ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXIN

Journal of Experimental Medicine, 1909
The foregoing and earlier data taken together demonstrate that an active immunity lasting several years can be produced in guinea-pigs, by the injection of toxin-antitoxin mixtures which have no recognizable harmful effect either immediate or remote ...
Theobald. Smith
semanticscholar   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia

Emerging Infectious Diseases, 2017
By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria.
Christine J. Doyle, Adam Mazins, Rikki M.A. Graham, Ning-Xia Fang, Helen V. Smith, Amy V. Jennison   +5 more
doaj   +1 more source

Infections in Chronic Lymphocytic Leukemia: Evolving Risks and Prevention Strategies

European Journal of Haematology, EarlyView.
ABSTRACT Infections remain a leading cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL), reflecting both intrinsic immune dysfunction and therapy‐related immunosuppression. The pathogenesis of immunodeficiency in CLL is multifactorial: neoplastic B cells impair humoral immunity, T cells are functionally exhausted, and ...
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Determination of low tetanus or diphtheria antitoxin titers in sera by a toxin neutralization assay and a modified toxin-binding inhibition test

Brazilian Journal of Medical and Biological Research, 2007
A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test).
M.H. Sonobe, A.G. Trezena, F.B. Guilhen, V.L. Takano, F. Fratelli, D. Sakauchi, J.F. Morais, S.M.A. Prado, H.G. Higashi   +8 more
doaj  

Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study

Emerging Infectious Diseases, 1999
In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination.
Hester E. de Melker, G.A.M. Berbers, N.J.D. Nagelkerke, M.A.E. Conyn-van Spaendonck   +3 more
doaj   +1 more source