Results 61 to 70 of about 51,558 (250)
Advanced Science, EarlyView.Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie +9 more
wiley +1 more source
Sequence Analysis of Toxin Gene–Bearing Corynebacterium diphtheriae Strains, Australia
Emerging Infectious Diseases, 2017 By conducting a molecular characterization of Corynebacterium diphtheriae strains in Australia, we identified novel sequences, nonfunctional toxin genes, and 5 recent cases of toxigenic cutaneous diphtheria.
Christine J. Doyle +5 more
doaj +1 more source
Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis [PDF]
, 2018 Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal morbidity and mortality in premature infants. Human and animal studies suggest a role for Paneth cells in NEC pathogenesis.
Elgin, Timothy G +11 more
core +3 more sources
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov +2 more
wiley +1 more source
On the Toxin Production of the Diphtheria Bacillus [PDF]
Epidemiology and Infection, 1912 Everyone who has been occupied with the weekly production of diphtheria toxin in quantity has been struck with the great variations which may and usually do occur in the strength of the toxin from week to week. It is indeed extraordinary as Madsen remarks (1908, p.
openaire +3 more sources
Research advancements and evaluation of multifactor‐induced murine models for gastric cancer
Animal Models and Experimental Medicine, EarlyView.Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang +5 more
wiley +1 more source
Diphtheria toxin: nucleotide binding and toxin heterogeneity. [PDF]
Proceedings of the National Academy of Sciences, 1980 We have used flow dialysis to demonstrate binding of ATP and related compounds to diphtheria toxin. The results define a new site on the toxin molecule (the P site), which has distinctly different properties from the NAD+-binding site of the fragment A moiety.
Robert J. Collier, Stephen Lory
openaire +3 more sources
Oligodendrogenesis in Evolution, Development and Adulthood
Glia, EarlyView.Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu +3 more
wiley +1 more source
Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study
Emerging Infectious Diseases, 1999 In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination.
Hester E. de Melker +3 more
doaj +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source