Results 71 to 80 of about 28,936 (237)
Allergy, EarlyView.Data were included from adolescents with moderate‐to‐severe AD treated with the JAK1 inhibitor abrocitinib (200 mg/100 mg) across JADE clinical trials. Improvements in skin clearance (per EASI‐75) and itch (per PP‐NRS4) were maintained for up to 112 weeks with both abrocitinib doses.
Amy S. Paller +13 more
wiley +1 more source
Shiga Toxin Detection Methods : A Short Review [PDF]
arXiv, 2013 The Shiga toxins comprise a family of related protein toxins secreted by certain types of bacteria. Shigella dysenteriae, some strain of Escherichia coli and other bacterias can express toxins which caused serious complication during the infection. Shiga toxin and the closely related Shiga-like toxins represent a group of very similar cytotoxins that ...
arxiv
Brazilian Journal of Medical and Biological Research, 2007 A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test).
M.H. Sonobe +8 more
doaj
Diphtheria toxin has the properties of a lectin. [PDF]
Proceedings of the National Academy of Sciences, 1978 The inhibition of protein synthesis in Chinese hamster V79 cells by diphtheria toxin is antagonized by the lectins concanavalin A, succinylated concanavalin A, and wheat germ agglutinin but not by Proteus vulgaris phytohemagglutinin or abrus agglutinin. The effects of concanavalin A and wheat germ agglutinin are reversed by methyl alpha-mannoside and N-
Draper, Rockford K. +2 more
openaire +5 more sources
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, EarlyView.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
NECESSITY OF TRANSLOCATION DOMAIN FOR REALISATION OF CYTOSTATIC EFFECT OF NON-TOXIC DERIVATIVES OF DIPHTHERIA TOXIN [PDF]
Biotechnologia Acta, 2018 The aim of the work was to evaluate in vitro the cytostatic effect of recombinant fragments of the non-toxic point mutant of diphtheria toxin — CRM197, which was suggested as a potent medication for treatment of triple negative breast cancer.
K. Y. Manoilov +4 more
doaj +1 more source
Sri Lankan Journal of Infectious Diseases, 2011 Diphtheria is a nearly eradicated disease in Sri Lanka. After introduction of EPI vaccination program in 1978 childhood diphtheria has been eradicated.
Rohitha Jayamaha
doaj +1 more source
Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, Volume 100, Issue 5, Page 860-891, May 2025.ABSTRACT Disease Overview Acute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the ...
Shai Shimony +2 more
wiley +1 more source
Toxin-allelopathy among phytoplankton species prevents competitive exclusion [PDF]
Journal of Biological Systems, 2006, 2006 Toxic or allelopathic compounds liberated by toxin-producing phytoplankton (TPP) acts as a strong mediator in plankton dynamics. On an analysis of a set of phytoplankton biomass-data that have been collected by our group in the North-West part of the Bay of Bengal, and by analysis of a three-component mathematical model under a constant as well as a ...
arxiv
CD11c‐Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells
Glia, Volume 73, Issue 5, Page 1077-1089, May 2025.Main Points Recognition of apoptotic cells drives transient microglial CD11c expression. CD11c microglia are highly phagocytic and have elevated lysosomal content. CD11c state is partly dependent on Axl and they transition out as apoptotic cells are cleared.
Nathaniel Ghena +6 more
wiley +1 more source