Results 81 to 90 of about 28,936 (237)
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Mengjie Guo +9 more
wiley +1 more source
The Dynamic Behavior (Effects) of Impulsive Toxicant Input on a Single-Species Population in a Small Polluted Environment [PDF]
arXiv, 2016 In this paper, we study a single-species population model with pulse toxicant input to a small polluted environment. The intrinsic rate of population is affected by environment and toxin in organisms. The toxin in organisms is influenced by toxin in environment and the food chain. A new mathematical model is derived.
arxiv
Late Presentation of Post Diphtheritic Myocarditis in a 15-year male
Journal of Nepal Medical Association, 2017 A 15-year old male patient presented to us with dyspnoea for four days. He had a history of fever, pseudo-membranous tonsillitis and cervical adenopathy twenty-five days prior to the presentation.
Kutty Sharada Vinod +3 more
doaj +1 more source
Advanced Science, Volume 12, Issue 14, April 10, 2025.Staphylococcus aureus (S. aureus) infection induces persistent pain via toxins, leading to CGRP release from TRPV1+ nociceptive nerves. CGRP inhibits chemotactic factor release from CX3CR1+ synovial lining macrophages and suppresses their bactericidal activity. This study highlights neuroimmune interactions in chronic septic arthritis and suggests CGRP
Xinyu Fang +19 more
wiley +1 more source
The receptor-toxin-antibody interaction: Mathematical model and numerical simulation [PDF]
arXiv, 2012 A reaction-diffusion model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values ...
arxiv
Interaction of diphtheria toxin (fragment A) with actin
Cell Biochemistry and Function, 2009 AbstractIt was shown by gel filtration and viscosity measurements that N‐terminal fragment (FA) of diphtheria toxin (DT) can interact with both G‐ and F‐actin (filamentous actin). Elution profiles on Sephadex G‐100 indicated the formation of a binary complex of fragment A (FA) with globular actin monomer (G‐actin), which was inhibited by gelsolin ...
Bektas, Muhammet +3 more
openaire +5 more sources
THE SCHICK TOXIN REACTION FOR IMMUNITY IN DIPHTHERIA [PDF]
Archives of Pediatrics and Adolescent Medicine, 1915 As is well known, immunity in diphtheria is generally incomplete and of short duration. Even an attack of this disease with consequent stimulation of the body cells with diphtheria toxin and the formation of homologous antitoxin and other antibodies does not confer for any considerable length of time that immunity which is so characteristic of scarlet ...
Kolmer, J. A., Moshage, E. L.
openaire +3 more sources
A solid approach to biopharmaceutical stabilisation [PDF]
, 2018 Ensilication is a technology we developed that can physically stabilise proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, for example, liquid-formulated vaccines with adjuvants, have poor thermal stability ...
arxiv +1 more source
Journal of Medical Virology, Volume 97, Issue 4, April 2025.ABSTRACT Regulatory T cells (Tregs) play a vital role in limiting inflammation and resolving the immune response after a viral infection. Within the central nervous system (CNS), Tregs are especially important for the protection of neurons, which have limited regenerative capacity, and the preservation of myelin sheaths, which support neuronal function
Vivek R. Singh, Lauren A. O'Donnell
wiley +1 more source
Characterization of a transgenic mouse model of chronic conditional platelet depletion
Research and Practice in Thrombosis and Haemostasis, 2019 Background Platelets are widely recognized for their role in maintaining hemostasis. Recently, platelets have become appreciated for their varying roles in immunity, neuroprotection, and other physiological processes.
Leah M. Wuescher +2 more
doaj +1 more source