Results 81 to 90 of about 89,499 (267)
Discover ChemistryDiphtheria toxin, a major virulence factor of Corynebacterium diphtheriae, continues to pose significant therapeutic challenges in the face of antimicrobial resistance. Flavonoids, owing to their structural diversity and bioactivity, represent attractive
Chidi Edbert Duru +4 more
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Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT The immune system is tasked with mounting effective responses to pathogens while preventing inflammation triggered by innocuous antigens, including those derived from self, food, and commensal microbes. This balance is especially critical in the intestine, where dietary and microbial antigens are constantly encountered.
Liuhui Fu, Dan R. Littman
wiley +1 more source
Nature CommunicationsCorynebacterium ulcerans is an emerging zoonotic pathogen which causes diphtheria-like infections. Although C. ulcerans is found in multiple domestic and wild animal species, most human cases are linked with pets.
Chiara Crestani +7 more
doaj +1 more source
Unique chemical reactivity of His-21 of CRM-197, a mutated diphtheria toxin [PDF]
, 1998 CRM-197 is a mutated diphtheria toxin (63 000 Da) widely used as a carrier protein of conjugated vaccines. Among the 14 histidines of CRM-197, His-21 was found to be modified selectively with iodoacetamide based reagents.
Uchida +17 more
core +2 more sources
Development of a Conjugate Vaccine Targeting Human IgE for Long‐Term Prevention of Anaphylaxis
Allergy, EarlyView.
Vincent Serra, Laurent L. Reber
wiley +1 more source
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Advanced Science, Volume 12, Issue 46, December 11, 2025.Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple models, secondary necrosis occurred regardless of gasdermin E presence, challenging prior claims and redefining the understanding of how apoptotic cells ...
Shubhangi Gavali +9 more
wiley +1 more source
Functional verification of the diphtheria toxin A gene in a recombinant system
Journal of Animal Science and Biotechnology, 2012 Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng +6 more
doaj +1 more source
International Journal of Infectious Diseases, 2020 Objective: To determine the seroprevalence of antibodies against of diphtheria, tetanus, and pertussis among Thai adolescents. Methods: A cross-sectional study was conducted among Thai adolescents aged 11–20 years who had completed five doses of ...
Pimpika Hanvatananukul +7 more
doaj +1 more source
Immunogenicity and safety of combined tetanus, reduced diphtheria, acellular pertussis vaccine when co-administered with quadrivalent meningococcal conjugate and human papillomavirus vaccines in healthy adolescents. [PDF]
, 2014 Objective: Current United States immunization recommendations for adolescents include vaccines against tetanus, diphtheria and pertussis (Tdap), human papillomavirus (HPV), and Neisseria meningitidis serogroups A, C, W-135, and Y. In this Phase IV study,
Alexanderian, David +8 more
core +1 more source
On the Toxin Production of the Diphtheria Bacillus [PDF]
Epidemiology and Infection, 1912 Everyone who has been occupied with the weekly production of diphtheria toxin in quantity has been struck with the great variations which may and usually do occur in the strength of the toxin from week to week. It is indeed extraordinary as Madsen remarks (1908, p.
openaire +2 more sources