Results 81 to 90 of about 362,065 (266)

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil   +11 more
wiley   +1 more source

Functional verification of the diphtheria toxin A gene in a recombinant system

open access: yesJournal of Animal Science and Biotechnology, 2012
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng   +6 more
doaj   +1 more source

The Terminator mouse is a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages

open access: yesKidney International, 2013
Biomedical research often requires primary cultures of specific cell types, which are challenging to obtain at high purity in a reproducible fashion. Here we engineered the murine Rosa26 locus by introducing the diphtheria toxin receptor flanked by loxP ...
Jiankan Guo   +6 more
semanticscholar   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

open access: yesGlia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola   +10 more
wiley   +1 more source

A Case of Diphtheria

open access: yesSri Lankan Journal of Infectious Diseases, 2011
Diphtheria is a nearly eradicated disease in Sri Lanka. After introduction of EPI vaccination program in 1978 childhood diphtheria has been eradicated.
Rohitha Jayamaha
doaj   +1 more source

Seroprevalence of antibodies against diphtheria, tetanus, and pertussis among healthy Thai adolescents

open access: yesInternational Journal of Infectious Diseases, 2020
Objective: To determine the seroprevalence of antibodies against of diphtheria, tetanus, and pertussis among Thai adolescents. Methods: A cross-sectional study was conducted among Thai adolescents aged 11–20 years who had completed five doses of ...
Pimpika Hanvatananukul   +7 more
doaj   +1 more source

Low Dose of IL‐2 Application for Graft‐Versus‐Host Disease Prophylaxis Following Haploidentical Stem Cell Transplantation

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Early low‐dose IL‐2 administration after haploidentical HSCT promotes the reconstitution of NK cells and regulatory T cells (Tregs), enhances their activation (CD122+, DNAM‐1+, NKG2D+, CD62L+), and increases plasma cytokines (IFN‐γ, TNF‐α, IL‐10, IL‐2).
Zheng‐Li Xu   +13 more
wiley   +1 more source

Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin

open access: yesJournal of Neuroscience, 2012
We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes a hair cell-specific transcription ...
Justin S. Golub   +6 more
semanticscholar   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan   +12 more
wiley   +1 more source

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