Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management
ABSTRACT Disease Overview Acute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the ...
Shai Shimony+2 more
wiley +1 more source
Single-species population models with age structure and psychological effect in a polluted environment [PDF]
This paper considers a single-population model with age structure and psychological effects in a polluted environment. We divide the single population into two stages of larval and adult structure. The model uses Logistic input, and the larvae are converted into adult bodies by constant ratio. We only consider adulthood.
arxiv
Dorsal lateral geniculate substructure in the Long-Evans rat: A cholera toxin B-subunit study [PDF]
This study describes the substructure of the dorsal lateral geniculate nucleus of the thalamus of the pigmented rat (Rattus norvegicus) based on the eye-of-origin of its retinal ganglion cell inputs. We made monocular intra-ocular injections of the B-subunit of cholera toxin (CTB), a sensitive anterograde tracer, in three adult male Long-Evans rats. In
arxiv +1 more source
Targeted Proximal Tubule Injury Triggers Interstitial Fibrosis and Glomerulosclerosis [PDF]
Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world and acute kidney injury (AKI) is now recognized as a major risk factor in its development.
Bijol, Vanesa+7 more
core +1 more source
Breaking barriers: Smart vaccine platforms for cancer immunomodulation
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari+11 more
wiley +1 more source
Biomedical research often requires primary cultures of specific cell types, which are challenging to obtain at high purity in a reproducible fashion. Here we engineered the murine Rosa26 locus by introducing the diphtheria toxin receptor flanked by loxP ...
Jiankan Guo+6 more
semanticscholar +1 more source
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi+14 more
core +2 more sources
Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley +1 more source
Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study
In a population-based study in the Netherlands, diphtheria antitoxin antibodies were measured with a toxin-binding inhibition assay in 9,134 sera from the general population and religious communities refusing vaccination.
Hester E. de Melker+3 more
doaj +1 more source
Does counseling increase sustained benefit of HAART among prison inmates after release to the community? [PDF]
The lack of sustained effectiveness of HAART after release to the community of HIV-infected inmates treated in prison was well demonstrated by Springer et al. in a recent article.
Babudieri, Sergio+4 more
core +1 more source