Results 81 to 90 of about 362,065 (266)
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil +11 more
wiley +1 more source
Functional verification of the diphtheria toxin A gene in a recombinant system
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng +6 more
doaj +1 more source
Biomedical research often requires primary cultures of specific cell types, which are challenging to obtain at high purity in a reproducible fashion. Here we engineered the murine Rosa26 locus by introducing the diphtheria toxin receptor flanked by loxP ...
Jiankan Guo +6 more
semanticscholar +1 more source
Development of a Conjugate Vaccine Targeting Human IgE for Long‐Term Prevention of Anaphylaxis
Allergy, EarlyView.
Vincent Serra, Laurent L. Reber
wiley +1 more source
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola +10 more
wiley +1 more source
Diphtheria is a nearly eradicated disease in Sri Lanka. After introduction of EPI vaccination program in 1978 childhood diphtheria has been eradicated.
Rohitha Jayamaha
doaj +1 more source
Objective: To determine the seroprevalence of antibodies against of diphtheria, tetanus, and pertussis among Thai adolescents. Methods: A cross-sectional study was conducted among Thai adolescents aged 11–20 years who had completed five doses of ...
Pimpika Hanvatananukul +7 more
doaj +1 more source
Early low‐dose IL‐2 administration after haploidentical HSCT promotes the reconstitution of NK cells and regulatory T cells (Tregs), enhances their activation (CD122+, DNAM‐1+, NKG2D+, CD62L+), and increases plasma cytokines (IFN‐γ, TNF‐α, IL‐10, IL‐2).
Zheng‐Li Xu +13 more
wiley +1 more source
We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin receptor (DTR) gene into the Pou4f3 gene, which encodes a hair cell-specific transcription ...
Justin S. Golub +6 more
semanticscholar +1 more source
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan +12 more
wiley +1 more source

