Results 11 to 20 of about 6,606 (156)

Maternal Analgesic Exposure and Fetal Ductal Constriction: A Prospective Cohort Study in Late Pregnancy. [PDF]

Birth Defects Res
ABSTRACT Objective To evaluate the association between maternal analgesic exposure in late pregnancy and fetal ductal and pulmonary hemodynamics using serial echocardiographic assessment, and to explore potential differences between metamizole and acetaminophen. Methods In this prospective cohort study, 67 third‐trimester pregnancies were evaluated: 47
Rocha IEGM, Nobre AC, Rocha BG, Siqueira PHB, Cândido EL, Brandão SCS.   +5 more
europepmc   +2 more sources

Tilidine and dipyrone (metamizole) in cold pressor pain: A pooled analysis of efficacy, tolerability, and safety in healthy volunteers

Clinical and Translational Science, 2021
The cold pressor test (CPT) is widely implemented and offers a simple, experimental acute pain model utilizing cold pain. Previous trials have frequently paired the CPT with opioids in order to investigate the mechanisms underlying pharmacological ...
Julian Kleine‐Borgmann, Johannes Wilhelmi, Johannes Kratel, Frederik Baumann, Katharina Schmidt, Matthias Zunhammer, Ulrike Bingel   +6 more
doaj   +1 more source

Excess Mortality in Aspirin and Dipyrone (Metamizole) Co‐Medicated Patients With Cardiovascular Disease: A Nationwide Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Pain is a major issue in our aging society. Dipyrone (metamizole) is one of the most frequently used analgesics. Additionally, it has been shown to impair pharmacodynamic response to aspirin as measured by platelet function tests.
Amin Polzin, Lisa Dannenberg, Carolin Helten, Martin Pöhl, Daniel Metzen, Philipp Mourikis, Christof Dücker, Ursula Marschall, Helmut L’Hoest, Beata Hennig, Saif Zako, Kajetan Trojovsky, Tobias Petzold, Christian Jung, Bodo Levkau, Tobias Zeus, Karsten Schrör, Thomas Hohlfeld, Malte Kelm   +18 more
doaj   +1 more source

Pharmacokinetic profiles of the active metamizole metabolites in healthy horses [PDF]

, 2016
Metamizole (MT) is an analgesic and antipyretic drug labelled for use in humans, horses, cattle, swine and dogs. MT is rapidly hydrolysed to the active primary metabolite 4-methylaminoantipyrine (MAA).
. LEE, Hk, Aupanun, S, Faillace, Vanessa, Giorgi, M, Laus, Fulvio, Poapolathep, A, Rychshanova, R, Vullo, Cecilia   +7 more
core   +1 more source

Dipyrone has no effects on bone healing of tibial fractures in rats [PDF]

Acta Ortopédica Brasileira, 2014
OBJECTIVE: To evaluate the effect of dipyrone on healing of tibial fractures in rats. METHODS: Fourty-two Wistar rats were used, with mean body weight of 280g.
Julio Cesar Gali, Dennis Sansanovicz, Fernando Carvalho Ventin, Rodrigo Henrique Paes, Francisco Carlos Quevedo, Edie Benedito Caetano   +5 more
doaj   +1 more source

Inhibition of human neutrophil oxidative burst by pyrazolone derivatives [PDF]

, 2006
The risk of agranulocytosis associated with the use of pyrazolone drugs at therapeutical doses and for short periods of time has been considered to be very low.
Costa, David, Fernandes, Eduarda, Lima, José L. F. C., Marques, A. P., Reis, R. L.   +4 more
core   +1 more source

Intravenous dipyrone for the acute treatment of episodic tension-type headache: A randomized, placebo-controlled, double-blind study

Brazilian Journal of Medical and Biological Research, 2002
Acute headaches are responsible for a significant percentage of the case load at primary care units and emergency rooms in Brazil. Dipyrone (metamizol) is easily available in these settings, being the most frequently used drug. We conducted a randomized,
M.E. Bigal, C.A. Bordini, J.G. Speciali
doaj   +1 more source

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties

Pharmaceuticals, 2022
Among the most recent proposals regarding the mechanism of action of dipyrone, the modulation of cannabinoid receptors CB1 and CB2 appears to be a promising hypothesis.
Daniela R. de Oliveira, Rodolfo C. Maia, Patrícia R. de Carvalho França, Patrícia D. Fernandes, Gisele Barbosa, Lídia M. Lima, Carlos A. Manssour Fraga   +6 more
doaj   +1 more source

Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis [PDF]

, 2011
A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations.
Durand Alegría, Jesús Senén, Fernández Hernando, Pilar, Narros Sierra, Adolfo, Pradana Pérez, Juan Angel   +3 more
core   +2 more sources

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

Chemosensors, 2022
The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the
Sarizhat D. Tataeva, Kurban E. Magomedov, Ruslan Z. Zeynalov, Naida D. Baygishieva, Viktorya S. Magomedova, Alina A. Rabadanova, Farid F. Orudzhev   +6 more
doaj   +1 more source