Results 11 to 20 of about 3,608 (185)

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties

Pharmaceuticals, 2022
Among the most recent proposals regarding the mechanism of action of dipyrone, the modulation of cannabinoid receptors CB1 and CB2 appears to be a promising hypothesis.
Daniela R. de Oliveira, Rodolfo C. Maia, Patrícia R. de Carvalho França, Patrícia D. Fernandes, Gisele Barbosa, Lídia M. Lima, Carlos A. Manssour Fraga   +6 more
doaj   +1 more source

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

Chemosensors, 2022
The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the
Sarizhat D. Tataeva, Kurban E. Magomedov, Ruslan Z. Zeynalov, Naida D. Baygishieva, Viktorya S. Magomedova, Alina A. Rabadanova, Farid F. Orudzhev   +6 more
doaj   +1 more source

Tilidine and dipyrone (metamizole) in cold pressor pain: A pooled analysis of efficacy, tolerability, and safety in healthy volunteers

Clinical and Translational Science, 2021
The cold pressor test (CPT) is widely implemented and offers a simple, experimental acute pain model utilizing cold pain. Previous trials have frequently paired the CPT with opioids in order to investigate the mechanisms underlying pharmacological ...
Julian Kleine‐Borgmann, Johannes Wilhelmi, Johannes Kratel, Frederik Baumann, Katharina Schmidt, Matthias Zunhammer, Ulrike Bingel   +6 more
doaj   +1 more source

Dipyrone has no effects on bone healing of tibial fractures in rats [PDF]

Acta Ortopédica Brasileira, 2014
OBJECTIVE: To evaluate the effect of dipyrone on healing of tibial fractures in rats. METHODS: Fourty-two Wistar rats were used, with mean body weight of 280g.
Julio Cesar Gali, Dennis Sansanovicz, Fernando Carvalho Ventin, Rodrigo Henrique Paes, Francisco Carlos Quevedo, Edie Benedito Caetano   +5 more
doaj   +1 more source

Intravenous dipyrone for the acute treatment of episodic tension-type headache: A randomized, placebo-controlled, double-blind study

Brazilian Journal of Medical and Biological Research, 2002
Acute headaches are responsible for a significant percentage of the case load at primary care units and emergency rooms in Brazil. Dipyrone (metamizol) is easily available in these settings, being the most frequently used drug. We conducted a randomized,
M.E. Bigal, C.A. Bordini, J.G. Speciali
doaj   +1 more source

Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice [PDF]

Veterinary and Comparative Biomedical Research
Pain relief is a crucial aspect of modern surgery. The analgesic used should possess strong analgesic properties, a rapid onset of action, and minimal side effects to effectively reduce pain during and after surgical procedures. Therefore, the aim of the
Mostafa Kalantari, Firouz Faedmaleki, Arya Soneishargh   +2 more
doaj   +1 more source

Dipyrone

Reactions Weekly, 2022
openaire   +3 more sources

Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1

PAIN Reports, 2019
. Introduction:. The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in ...
Stefan Alexander Schenk, Felicia Dick, Christine Herzog, Mirjam Jeanette Eberhardt, Andreas Leffler   +4 more
doaj   +1 more source

Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone?

Brazilian Journal of Medical and Biological Research, 2003
It was previously reported that systemic administration of dipyrone inhibited the tonic component of generalized tonic-clonic seizures in both the electroshock and the audiogenic seizure models.
G.M.L. Reis, M.C. Doretto, I.D.G. Duarte, M.A.K.F. Tatsuo   +3 more
doaj   +1 more source

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2019
Objective To compare low doses of pethidine with dipyrone in labor analgesia. Methods In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients ...
Rogevando Rodrigues Nunes, André Montenegro Primo   +1 more
doaj   +1 more source