Results 51 to 60 of about 3,844,628 (256)
The ‘Viennese epidemic’ of acute HCV in the era of direct-acting antivirals
Journal of Hepatology, 2022 AbstractThe recently reported epidemic of acute hepatitis C virus (HCV) infections —observed predominantly among men who have sex with men (MSM)—may now decline due to wide availability of direct‐acting antivirals (DAAs). This study aimed to investigate the current trends of acute hepatitis C in Vienna.
David Chromy +13 more
openaire +2 more sources
Hepatic decompensation associated with an interferon-free antiviral therapy in patients with HCV-cirrhosis [PDF]
Терапевтический архив, 2018 Today, there is no complete clarity about the pathogenetic mechanisms of the hepatic decompensation in patients with HCV-cirrhosis during the course of direct-acting antiviral (DAAs) therapy. The current article describes several clinical observations of
S N Batskikh +3 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Causes of treatment failure for hepatitis C in the era of direct-acting antiviral therapy [PDF]
, 2016 Hepatitis C therapy in the era of the newer direct-acting antiviral agents has radically changed our treatment schemes by achieving very high rates of sustained virological response.
Puente,Ángela +4 more
core +1 more source
Hepatitis C Virus Infection in Europe
PathogensThe Hepatitis C Virus (HCV) is a significant public health challenge in European countries. Historically, healthcare-related procedures were the primary source of HCV infection in Europe.
Margarida Simão, Cristina Gonçalves
doaj +1 more source
Virus infection and direct-acting antivirals in pregnancy
Clinical and Experimental Obstetrics & Gynecology, 2022 Objective: Antiviral therapy during pregnancy has always presented difficulties in clinical practice. This review covers the safety and efficacy of the direct use of antivirals during pregnancy. Mechanism: We conducted literature research to summarize the available evidence on the use of direct-acting antivirals during pregnancy for infections due to ...
Xuan Huang, Jing Tang
openaire +2 more sources
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Antiviral therapy of HCV-cirrhosis: case of sequential treatment and review of literature [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2018 This clinical case demonstrates a history of 40-year old male with decompensated liver cirrhosis due to hepatitis C (genotype 1). The patient was started on direct acting antiviral therapy with sofosbuvir and simeprevir in order to decrease rate of ...
Kakharman Yesmembetov +2 more
doaj +1 more source
, 2022 P36 Outcomes of general practitioner prescription of direct acting antiviral therapy utilising a remote consultation referral pathway in Western ...
M Wardrop (13356459) +6 more
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