Results 61 to 70 of about 3,844,628 (256)

Late Relapse and Reinfection in HCV Patients Treated with Direct-Acting Antiviral (DAA) Drugs

, 2021
The risk of hepatitis C virus (HCV) recurrence after direct-acting antiviral (DAA) treatment is Z-score of
Chiara Taibi, Mauro Zaccarelli, Andrea Antinori, Fiona McPhee, Cesare E. M. Gruber, Martina Rueca, Marzia Montalbano, Elisabetta Grilli, Claudia Minosse, Gianpiero D’Offizi, Anna Rosa Garbuglia, Maria R. Capobianchi   +11 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Treating Hepatitis C Virus Infection in Jails as an Offset to Declines in Treatment Activity in the Community, New York City, NY, 2014–2020

AJPM Focus
Introduction: There are scant data on implementation of large-scale direct-acting antiviral treatment for hepatitis C virus in jails in the U.S. New York City Health + Hospitals/Correctional Health Services aimed to scale up hepatitis C virus treatment ...
Justin Chan, MD, Matthew J. Akiyama, MD, Emily Julian, RN, Rodrigue Joseph, MD, Wendy McGahee, MD, Zachary Rosner, MD, Patricia Yang, DrPH, Ross MacDonald, MD   +7 more
doaj   +1 more source

CIRCULATING MIRNA-122, MIRNA-155, AND MIRNA- 200 AS PREDICTORS FOR HEPATOCELLULAR CARCINOMA OCCURRENCE IN EGYPTIAN PATIENTS WITH HEPATITIS C RELATED LIVER CIRRHOSIS TREATED WITH DIRECT ACTING ANTIVIRAL DRUGS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Background and aim: Hepatocellular carcinoma (HCC) is commonly attributed to cirrhosis related to chronic HCV infection. We aimed to evaluate the occurrence and the risk factors of HCC as well as assessment of the novel markers for HCC in patients ...
Hanan Nafeh, Alshaimaa Rafat, Sahar Hassany, Abdelmajeed Moussa, Helal Hetta   +4 more
doaj   +1 more source

Retreatment for hepatitis C virus direct-acting antiviral therapy virological failure in primary and tertiary settings: The REACH-C cohort

, 2022
Retreatment for hepatitis C virus direct-acting antiviral therapy virological failure in primary and tertiary settings: The REACH-C ...
A Wade (9863456), J Ackerman (13312530), C Hey (13312548), L Davidson (7730780), J Yee (13312452), R Deacon (13312533), TM Soo (15868859), S Holdaway (13312509), JS Doyle (9722705), R Batey (13312464), J Smart (13312467), S Hill (7786433), Christine Roder (13065378), M Milner (13286148), R Bopage (13312494), K Tan (7719896), J Post (8831441), GJ Dore (14543678), B Harney (7782593), B Hajarizadeh (12496642), J Tate-Baker (13312542), P Fox (13312512), G Snelgar (13312485), H Van Gessel (13312503), J Stewart (9891653), G Baluran (13312545), O Dawson (13312470), S Galhenage (13312488), L Cooper (13280709), D Baker (7724024), M Martinello (13376178), S Hinton (9879371), C Orme (13312554), R Ahmad (7777727), M Wilson (7738082), S Miczkova (13312557), E Silins (13312527), J Bradshaw (9578645), R Nelson (7678238), J Hanson (7791434), R Hickey (13312551), J Davies (7777496), W Pratt (13312500), D Smith (12025), D Iser (9722720), D Shaw (7814597), J O'Beirne (13483459), M Montebello (13312476), A Balcomb (13312446), P Marks (9859076), M Douglas (13312473), M Dibdin (13312506), A Everson (13312539), J Walsh (7691909), JM Carson (14543675), C Ferguson (7634273), W Lam (13297200), E Hall (13312536), R Hallinan (13312482), G Duncan (7670348), R Gilliver (13312524), B Watson (7734923), P Read (11380298), P Collie (13312479), J Faros (13312497), GV Matthews (14543681), RP Dahal (15868862), M Lucas (4244428), R Mousavi (13312515), P Habel (13312521)   +69 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Computer-aided identification of a series of novel ligands showing high potency as hepatitis C virus NS3/4A protease inhibitors

Bulletin of the National Research Centre, 2021
Background Hepatitis C virus (HCV) is a global medical condition that causes several life-threatening chronic diseases in the liver. The conventional interferon-free treatment regimens are currently in use by a blend of direct-acting antiviral agents ...
Stephen Ejeh, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

The European Prevalence of Resistance Associated Substitutions among Direct Acting Antiviral Failures

Viruses, 2021
Background: Approximately 71 million people are still in need of direct-acting antiviral agents (DAAs). To achieve the World Health Organization Hepatitis C elimination goals, insight into the prevalence and influence of resistance associated ...
Stephanie Popping, Valeria Cento, Carole Seguin-Devaux, Charles A. B. Boucher, Adolfo de Salazar, Eva Heger, Orna Mor, Murat Sayan, Dominique Salmon-Ceron, Nina Weis, Henrik B. Krarup, Robert J. de Knegt, Oana Săndulescu, Vladimir Chulanov, David A. M. C. van de Vijver, Federico García, Francesca Ceccherini-Silberstein   +16 more
doaj   +1 more source

Metabolism of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy: A Review of the Literature

, 2021
Background: Hepatitis C virus (HCV) infection is still one of the leading causes of chronic liver disease, with chronically infected making up approximately 1% of the global population.
Virović-Jukić, Lucija, Puljiz, Željko, Delija, Božena, Jurić, Toni, Mikolašević, Ivana, Božic, Dorotea, Radić-Kristo, Delfa, Mijić, Maja, Bogadi, Ivan, Shapeski, Sanja S., Filipec Kanižaj, Tajana., Puž, Petra, Lalovac, Miloš, Dorotea Bozic, Lucija Virovic-Jukic, Ivan Bogadi, Zeljko Puljiz, Delfa Radic-Kristo, Sanja S. Shapeski, Maja Mijic, Ivana Mikolasevic, Bozena Delija, Toni Juric, Tajana F. Kanizaj, Milos Lalovac, Petra Puz   +25 more
core   +1 more source

Direct‐Acting Antiviral Therapy and Hepatocellular Carcinoma [PDF]

Clinical Liver Disease, 2021
Nicole E. Rich, Amit G. Singal
openaire   +2 more sources