Results 81 to 90 of about 3,844,628 (256)
, 2019 Sustained virologic response rates (95% confidence intervals) in participants with HCV GT1 infection who initiated direct-acting antiviral treatmenta.
David Muschi (7300049) +5 more
core +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Direct-acting antivirals for flaviviruses.
, 2022 Direct-acting antivirals for flaviviruses.
Vinod RMT Balasubramaniam (12475307) +3 more
core +1 more source
Current and Future Direct-Acting Antivirals Against COVID-19 [PDF]
Frontiers in Microbiology, 2020 The coronavirus disease of 2019 (COVID-19) has caused an unprecedented global crisis. The etiological agent is a new virus called the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). As of October, 2020 there have been 45.4 million confirmed cases with a mortality rate of 2.6% globally.
openaire +3 more sources
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
The Turkish Journal of Gastroenterology, 2019 INTRODUCTION: The aim of the present study was to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir (LDV/SOF) with or without ribavirin (RBV), and Ombitasvir- ritonavir/Paritaprevir/Dasabuvir (PrOD) with or without RBV in the treatment of ...
Aysun Kartal +7 more
doaj +1 more source
, 2018 Changes in health-related quality of life scores from the baseline to the week 4 of treatment with direct-acting antiviral agents.
Regina Juanbeltz (5832653) +5 more
core +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Hepatic Medicine: Evidence and Research, 2019 David Bernstein,1 Rakesh Tripathi,2 Daniel E Cohen2 1Zucker School of Medicine, Hofstra University, Hempstead, New York, NY, USA; 2AbbVie Inc., North Chicago, IL, USA Background: This international, phase 2, open-label, multicenter study (ClinicalTrials ...
Bernstein D, Tripathi R, Cohen DE
doaj
, 2018 Changes in health-related quality of life scores from the baseline to the week 12 post-treatment with direct-acting antiviral agents.
Regina Juanbeltz (5832653) +5 more
core +1 more source