Results 91 to 100 of about 3,844,628 (256)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study [PDF]

, 2019
Direct-acting antiviral agents (DAAs) are extremely effective in eradicating hepatitis C virus (HCV) in chronically infected patients. However, the protective role of the sustained virologic response (SVR) achieved by second- and third-generation DAAs ...
Sechi L. A., Soardo G., Catena, C., Brizzi, R. F., Catena C., Valenti, L., Colussi G., Brizzi R. F., Colussi, G., Cavarape A., Sechi, L. A., Valenti L., Donnini, D., Donnini D., Soardo, G., Maier, S., Cavarape, A., Maier S.   +17 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Autoimmune manifestations and direct-acting antiviral drugs in Egyptian patients with hepatitis C virus infection: A cohort study

Journal of International Medical Research
Objectives To investigate the clinical and serological features of autoimmunity with chronic hepatitis C virus infection before and after direct-acting antiviral therapy and assess their relation to treatment response.
Hesham I Elmakhzangy, Mai A Rabie, Dina MR Bahgat, Doaa HS Attia, Ahmed ET Elsayed, Reem Hamdy A Mohammed   +5 more
doaj   +1 more source

Anti-E1E2 antibodies status prior therapy favors direct-acting antiviral treatment efficacy

, 2018
International audiencePresence of anti-E1E2 antibodies was previously associated with spontaneous cure of hepatitis C virus (HCV) and predictive before treatment of a sustained virological response (SVR) to bi- or tri-therapy in naïve or experienced ...
Caroline Scholtès, Christian Trépo, Leroy, Vincent, Scholtes, Caroline, Marie-Anne Petit, Sylvie Larrat, Isabelle Chemin, Petit, Marie-Anne, Virlogeux, Victor, Crouy, Stéphanie, Bordes, Isabelle, Zoulim, Fabien, Pascale Berthillon, Berthillon, Pascale, Larrat, Sylvie, Victor Virlogeux, Pierre Pradat, Marianne Maynard, Chemin, Isabelle, Maynard, Marianne, Fabien Zoulim, Pradat, Pierre, Isabelle Bordes, Stéphanie Crouy, Vincent Leroy, Trépo, Christian   +25 more
core   +1 more source

Direct-acting antiviral agents in the therapy of hepatitis C virus-related mixed cryoglobulinaemia: a single-centre experience [PDF]

, 2017
The efficacy and safety of direct-acting antiviral agents (DAAs) were evaluated in a cohort of prospectively enrolled patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC), an immune complex-mediated vasculitis of small and medium ...
Fabio Pavone, PAVONE, FABIO, Dammacco, Franco, Gianfranco Lauletta, Sabino Russi, Angelo Vacca, Franco Dammacco, RUSSI, SABINO, LAULETTA, GIANFRANCO, VACCA, Angelo   +9 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Comparison of clinical outcomes and impact of SVR in American and Chinese patients with chronic hepatitis C

JHEP Reports, 2020
Background & Aims: Chronic HCV infection is an important cause of hepatocellular carcinoma (HCC) and liver failure in the US but limited data are available in China.
Huiying Rao, Huixin Liu, Elizabeth Wu, Ming Yang, Bo Feng, Andy Lin, Ran Fei, Robert J. Fontana, Lai Wei, Anna S. Lok   +9 more
doaj   +1 more source