Results 111 to 120 of about 29,513 (309)
Bioequivalent pharmacokinetics for generic and originator hepatitis C direct-acting antivirals
Journal of Virus Eradication, 2018 Mass production of low-cost, generic direct-acting antivirals (DAAs) will be required to achieve targets of eliminating hepatitis C (HCV) by 2030. The pharmaceutical companies Gilead and Bristol-Myers Squibb have granted voluntary licences (VLs) to ...
Andrew Hill +8 more
doaj +1 more source
The role of iron related gene variants in liver disease severity and iron metabolism parameters in chronic hepatitis C patients treated with direct-acting antivirals [PDF]
, 2019 Chronic hepatitis C (CHC) is usually associated with iron overload, which may modulate the severity of liver disease. Direct-acting antivirals (DAAs) have made HCV treatment faster and more efficient.
Bicho, Manuel +3 more
core
Norovirus antiviral discovery: host-modulators and direct-acting antivirals
, 2018 Human norovirus is a leading cause of acute gastroenteritis (AGE) worldwide and is estimated to be responsible for over 200,000 deaths each year. Norovirus infections are estimated to cost $60 billion in societal costs globally each year. Yet despite the substantial health and economic burden of norovirus, there is no vaccine or norovirus-specific ...
openaire +2 more sources
Advanced Science, EarlyView.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
New Potential Therapies for Chronic Hepatitis B
The Korean Journal of Gastroenterology, 2019 A HBV infection is a dynamic disease and long-term liver inflammation contributes to the development of liver cirrhosis and hepatocellular carcinoma. Currently available nucleos(t)ide analogues and pegylated interferon are effective in inhibiting HBV ...
Sun Hong Yoo, Jung Hyun Kwon
doaj +1 more source
Ready or Not? Protecting the Public's Health From Diseases, Disasters, and Bioterrorism, 2008 [PDF]
, 2008 Examines ten indicators to assess progress in state readiness to respond to bioterrorism and other public health emergencies. Evaluates the federal government's and hospitals' preparedness.
Jeffrey Levi +3 more
core +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Potential Therapeutic Agents for Feline Calicivirus Infection
Viruses, 2018 Feline calicivirus (FCV) is a major cause of upper respiratory tract disease in cats, with widespread distribution in the feline population. Recently, virulent systemic diseases caused by FCV infection has been associated with mortality rates up to 50 ...
Tulio M. Fumian +6 more
doaj +1 more source
Recommendation for Routine Prenatal Screening for Hepatitis C [PDF]
, 2018 Hepatitis C prevalence and incidence are on the rise, both nationally and in Vermont. This project aims to assess the feasibility and potential benefit of implementing routine prenatal Hepatitis C screening, as opposed to screening only patients who fall
Morrison, Althea L
core +1 more source
Advanced Science, EarlyView.An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu +4 more
wiley +1 more source