The role of iron related gene variants in liver disease severity and iron metabolism parameters in chronic hepatitis C patients treated with direct-acting antivirals [PDF]
, 2019 Chronic hepatitis C (CHC) is usually associated with iron overload, which may modulate the severity of liver disease. Direct-acting antivirals (DAAs) have made HCV treatment faster and more efficient.
Bicho, Manuel +3 more
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Drug–Drug Interactions of Newly Approved Direct-Acting Antiviral Agents in Patients with Hepatitis C
, 2021 Lu-Hua Gao, Qing‐He Nie, X. Zhao
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SDS‐CRISPR for Single‐Nucleotide Variant Detection
Advanced Science, EarlyView.Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan +12 more
wiley +1 more source
Pangenotypic Direct Acting Antivirals Treatment for Chronic Hepatitis C Infection
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020 Juferdy Kurniawan
doaj +1 more source
Toward a Functional Cure for Hepatitis B
Gut and LiverCurrent treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular ...
Anna S. F. Lok
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Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation
Advanced Science, EarlyView.Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang +4 more
wiley +1 more source
4CPS-090 Health outcomes using direct-acting antiviral drugs for the treatment of patients with hepatitis C virus and F0–F1 liver fibrosis stage [PDF]
, 2019 M Martín López +5 more
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Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers
Advanced Science, EarlyView.This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu +9 more
wiley +1 more source