Results 181 to 190 of about 34,959 (356)

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Treatment with Direct-Acting Antivirals in Patients with HCV Infection After Liver Transplantation. [PDF]

J Clin Med
Brzdęk M, Zarębska-Michaluk D, Tronina O, Laurans Ł, Janczewska E, Dybowska D, Parfieniuk-Kowerda A, Tudrujek-Zdunek M, Białkowska-Warzecha J, Janocha-Litwin J, Flisiak R.   +10 more
europepmc   +1 more source

Influenza in today: direct-acting antiviral therapy

Медицинский совет, 2015
Influenza is an acute infectious disease caused by influenza virus (Orthomyxoviridae family) which affects up to 15% of the world population in the cold season. The relevance of the disease is reflected in the statistics: every year, up to 500 million people get sick with influenza globally, of which 2 million cases are fatal.
openaire   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Direct-Acting Antivirals Are a Milestone for Hepatitis C Virus Infection? Analysis of 15 Years of Patient and Diagnosis Data from a Region in Türkiye. [PDF]

J Clin Med
Yakupogullari Y, Tanrıverdi ES, Otlu B.
europepmc   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

Clinical relevance of detectable HCV RNA in the context of direct acting antivirals. [PDF]

, 2012
Crosbie, Orla, Fanning, Liam J., Hegarty, Kevin G., Kenny-Walsh, Elizabeth, Levis, John, O'Sullivan, Kathleen   +5 more
core   +1 more source

Direct-acting antivirals for chronic hepatitis C infection: a protocol for a systematic review of observational studies. [PDF]

Syst Rev
Kumburegama BWMB, Kristensen AT, Bjelakovic G, Nikolova D, Asante MA, Bjelakovic M, Koretz RL, Balakumar MM, Michelsen ME, Klingenberg SL, Gluud C.   +10 more
europepmc   +1 more source

Cryoglobulinaemic vasculitis in a patient with chronic hepatitis C: favourable outcome due to direct-acting antivirals.

, 2020
M.J.M. Boderie, Pieter van Paassen, Joop P. Aendekerk, Dirk Posthouwer   +3 more
openalex   +1 more source

Minimum Costs for Producing Hepatitis C Direct-Acting Antivirals for Use in Large-Scale Treatment Access Programs in Developing Countries [PDF]

, 2014
Alison L. Hill, Saye Khoo, Joseph Fortunak, Bryony Simmons, Nathan Ford   +4 more
openalex   +1 more source