Results 11 to 20 of about 3,248 (169)

Development of Amlodipine Mini-tablets as a Polypill-component for the Personalized Therapy of Arterial Hypertension

Разработка и регистрация лекарственных средств, 2023
Introduction. A personalized choice of antihypertensive combinations and doses is one of the promising trend in the field of combination therapy of arterial hypertension (AH).
K. M. Tserkovnaya, E. V. Flisyuk, Ju. M. Kotsur, I. A. Narkevich, I. E. Smekhova, D. Yu. Ivkin, N. V. Filimonova   +6 more
doaj   +1 more source

Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers

Pharmaceutics, 2023
The processing of liquisolid systems (LSS), which are considered a promising approach to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the relatively high amount of liquid phase incorporated within them.
Teodora Glišić, Jelena Djuriš, Ivana Vasiljević, Jelena Parojčić, Ivana Aleksić   +4 more
doaj   +1 more source

Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression

Pharmaceutics, 2022
Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) was used as a model drug to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors ...
Qiuhua Luo, Qianying Zhang, Puxiu Wang
doaj   +1 more source

Study of the quantitative factors influence on pharmaco-technological properties of powder masses and tablets with plant extracts and essential oil

Фармацевтичний журнал, 2021
The available range of phytopreparations for topical use in the oral cavity does not fully meet the needs of patients as mainly medicinal plant raw materials and tinctures of domestic production represent it.
O. I. Hordiienko, T. A. Hroshovyi
doaj   +1 more source

SeDeM as a Tool to Validate Drug Substance Manufacturing Processes and Assess Scalability and Suitability for Direct Compression: Supplier Screening

Pharmaceutics, 2023
During the development of an oral solid form of a drug substance, a thorough understanding of the critical material attributes is necessary, as the physical properties of the active pharmaceutical ingredient (API) can profoundly influence the drug ...
Alba Figuera-Figuera, Marc Suñé-Pou, Pilar Pérez-Lozano, Encarna García-Montoya, Joaquim Amela-Navarro, Josep M. Suñé-Negre   +5 more
doaj   +1 more source

Modelling the Compaction Step of a Platform Direct Compression Process

Pharmaceutics, 2022
The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs.
Raghu V. G. Peddapatla, Conor Slevin, Gerard Sheridan, Caoimhe Beirne, Shrikant Swaminathan, Ivan Browning, Clare O’Reilly, Zelalem A. Worku, David Egan, Stephen Sheehan, Abina M. Crean   +10 more
doaj   +1 more source

Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

Marine Drugs, 2020
Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques ...
Deeb Abu Fara, Linda Al-Hmoud, Iyad Rashid, Babur Z. Chowdhry, Adnan Badwan   +4 more
doaj   +1 more source

Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

Pharmaceuticals, 2022
Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study their ...
Tarek A. Ahmed, Hanadi A. Alotaibi, Waleed S. Alharbi, Martin K. Safo, Khalid M. El-Say   +4 more
doaj   +1 more source

Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

Pharmaceutics, 2020
It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage ...
Yingxi Zhang, Yuan Gao, Xiaoxiao Du, Rou Guan, Zhonggui He, Hongzhuo Liu   +5 more
doaj   +1 more source

Development of the technology of tablets on the basis of ademetionine 1,4-butanedisulfonate

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
During medicinal product development a lot of key points should be taken into consideration. The purpose of pharmaceutical development is not only the creation of effective and safe preparation but also the organization of appropriate conditions for the ...
K. S. Burdak, T. G. Yarnyh, M. I. Borshchevska   +2 more
doaj   +1 more source