Cross‐Sectional Studies: Strengths, Limitations, and Methodological Considerations
Cross‐sectional studies measure variables at a single time point to estimate prevalence and support descriptive epidemiology ‐ characterizing population health, tracking trends via repeated surveys – and for developing and validating screening instruments and diagnostic models.
Sebastian‐Edgar Baumeister +4 more
wiley +1 more source
The target trial framework is a pragmatic roadmap for observational causal inference that clarifies questions, mitigates time‐related bias, and improves interpretability while acknowledging limits. With transparent protocols, appropriate methods, and suitable data, it can complement randomized trials and inform practice and policy.
Sebastian‐Edgar Baumeister +6 more
wiley +1 more source
Study Design in Clinical and Epidemiologic Research: Observational, Experimental, and Beyond
Population‐based epidemiology and clinical research are complementary and mutually reinforcing: Epidemiology quantifies disease incidence/prevalence and elucidates environmental and social determinants in populations, whereas clinical research evaluates biomarkers, therapeutics, and prognostic outcomes in patients; their convergence underpins ...
Gustavo G. Nascimento +3 more
wiley +1 more source
Rethinking animal attrition in preclinical research: Expressing causal mechanisms of selection bias using directed acyclic graphs. [PDF]
Collazo A +4 more
europepmc +1 more source
The association between COVID‐19 vaccines and bullous pemphigoid risk: A UK population‐based study
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Mikolaj Swiderski +7 more
wiley +1 more source
The IMPOSTERS study analysed 150 recurring ‘human’ Simpsons characters and found that periodontitis or tooth loss was associated with a 23‐fold higher hazard of all‐cause mortality. This was reported in the Simpsons universe, with the death of ‘Bleeding Gums’ Murphy, 3 years before the first such reports in our universe.
Praveen Sharma, Thomas Dietrich
wiley +1 more source
Cohort and Case–Control Studies: Strengths, Limitations and Methodological Considerations
Population‐based epidemiology and clinical research are complementary by design—and nowhere is that more evident than in cohort studies. By following individuals over time, cohorts quantify disease incidence, elucidate environmental and social determinants and evaluate biomarkers and prognostic outcomes within a single longitudinal framework.
Nasir Z. Bashir +4 more
wiley +1 more source
Insomnia and Snoring in Relation to Future Psychological Distress and Daytime Symptoms in Women
ABSTRACT Anxiety, depression and daytime symptoms (sleepiness, tiredness) are overrepresented in people with snoring and insomnia, but the associations are not completely understood. We aimed to investigate relationships between insomnia and snoring with future psychological distress and daytime symptoms.
Galileo Frustaci +2 more
wiley +1 more source
Maternal Dietary Inflammatory Index and Biomarkers of Inflammation at Birth
ABSTRACT We evaluated the association between the inflammatory potential of the maternal diet during pregnancy and levels of inflammatory biomarkers measured in cord blood and maternal serum at birth. Dietary inflammatory potential was calculated using the energy‐adjusted dietary inflammatory index (E‐DII) in the French EDEN and ELFE birth cohorts ...
Courtney Dow +9 more
wiley +1 more source
Incident Lung Cancer and Mortality: Data From Health ABC Using Periodontal Status and Tooth Loss
ABSTRACT Aim To evaluate whether periodontal parameters and tooth loss are associated with lung cancer incidence and mortality among older adults. Materials and Methods Data are from the Health, Aging and Body Composition (Health ABC) study, which included 1136 older adults who received a periodontal examination and were followed for up to 16 years ...
Taciane Menezes da Silveira +5 more
wiley +1 more source

