Results 41 to 50 of about 493,855 (292)
Directed evolution converts subtilisin E into a functional equivalent of thermitase [PDF]
, 1999 We used directed evolution to convert Bacillus subtilis subtilisin E into an enzyme functionally equivalent to its thermophilic homolog thermitase from Thermoactinomyces vulgaris.
Arnold, Frances H., Zhao, Huimin
core +2 more sources
Transport of fullerene molecules along graphene nanoribbons [PDF]
, 2012 We study the motion of C60 fullerene molecules (buckyballs) and short-length carbon nanotubes on graphene nanoribbons. We demonstrate that the nanoribbon edge creates an effective potential that keeps the carbon structures on the surface.
Kivshar, Yuri S., Savin, Alexander V.
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Directional mutation pressure and neutral molecular evolution. [PDF]
Proceedings of the National Academy of Sciences, 1988 A quantitative theory of directional mutation pressure proposed in 1962 explained the wide variation of DNA base composition observed among different bacteria and its small heterogeneity within individual bacterial species. The theory was based on the assumption that the effect of mutation on a genome is not random but has a directionality toward ...
openaire +2 more sources
, 2010 Using coarse-grained molecular-dynamics simulations, a generic styrene-(block)-butadiene-(block)-styrene (SBS) triblock copolymer under lamellar conformation is used in order to investigate the mutual entanglement evolution when a structure of ...
Léonforte, F.
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
In-vitro engineering of novel bioactivity in the natural enzymes
Frontiers in Chemistry, 2016 Enzymes catalyze various biochemical functions with high efficiency and specificity. In-vitro design of the enzyme leads to novel bioactivity in this natural biomolecule that give answers of some vital questions like crucial residues in binding with ...
Vishvanath Tiwari
doaj +1 more source
Quantification of evolved DNA-editing enzymes at scale with DEQSeq
Genome Biology, 2023 We introduce DEQSeq, a nanopore sequencing approach that rationalizes the selection of favorable genome editing enzymes from directed molecular evolution experiments.
Lukas Theo Schmitt +8 more
doaj +1 more source
Directed Evolution and High-level Expression of α-Amylase from Thermomyces dupontii
Shipin gongye ke-ji, 2022 Objective: The α-amylase from Thermomyces dupontii was modified by direct evolution to improve its thermostability and expression level. Methods: A mutation library of α-amylase (Td-amy) from Thermomyces dupontii was constructed by error-prone PCR.
Yan JIN +5 more
doaj +1 more source
HD101584: Circumstellar characteristics and evolutionary status
, 2019 We have performed a study of the characteristics of the circumstellar environment of the binary object HD101584, that provides information on a likely evolutionary scenario.
Bergman, P. +10 more
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Clinical Insights Into Hypercalcemia of Malignancy in Childhood
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley +1 more source