Results 51 to 60 of about 495,896 (276)
In-vitro engineering of novel bioactivity in the natural enzymes
Frontiers in Chemistry, 2016 Enzymes catalyze various biochemical functions with high efficiency and specificity. In-vitro design of the enzyme leads to novel bioactivity in this natural biomolecule that give answers of some vital questions like crucial residues in binding with ...
Vishvanath Tiwari
doaj +1 more source
Quantification of evolved DNA-editing enzymes at scale with DEQSeq
Genome Biology, 2023 We introduce DEQSeq, a nanopore sequencing approach that rationalizes the selection of favorable genome editing enzymes from directed molecular evolution experiments.
Lukas Theo Schmitt +8 more
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, 2010 Using coarse-grained molecular-dynamics simulations, a generic styrene-(block)-butadiene-(block)-styrene (SBS) triblock copolymer under lamellar conformation is used in order to investigate the mutual entanglement evolution when a structure of ...
Léonforte, F.
core +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
HD101584: Circumstellar characteristics and evolutionary status
, 2019 We have performed a study of the characteristics of the circumstellar environment of the binary object HD101584, that provides information on a likely evolutionary scenario.
Bergman, P. +10 more
core +1 more source
Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]
, 2013 John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D +2 more
core +1 more source
Transposon-Based Approaches for Generating Novel Molecular Diversity During Directed Evolution [PDF]
, 2014 This chapter introduces a set of transposon-based methods that were developed to sample trinucleotide deletion, trinucleotide replacement, and domain insertion. Each approach has a common initial step that utilizes an engineered version of the Mu transposon called MuDel.
Jones, Darran Dafydd +3 more
openaire +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Directed Flow in Microscopic Models in Relativistic A+A Collisions
Universe, 2019 Evolution of directed flow of charged particles produced in relativistic heavy-ion collisions at energies 4 ≤ s ≤ 19.6 GeV is considered within two microscopic transport models, ultra-relativistic quantum molecular dynamics (UrQMD) and ...
Larissa Bravina +4 more
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Microorganisms, 2020 To improve the thermostability of tryptophan synthase, the molecular modification of tryptophan synthase was carried out by rational molecular engineering.
Lisheng Xu +3 more
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