Biological evolution through mutation, selection, and drift: An introductory review
, 1999 Motivated by present activities in (statistical) physics directed towards biological evolution, we review the interplay of three evolutionary forces: mutation, selection, and genetic drift.
Baake, Ellen, Gabriel, Wilfried
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Optimized expression and specific activity of IL-12 by directed molecular evolution [PDF]
Proceedings of the National Academy of Sciences, 2003 DNA delivery of IL-12 has shown promise in reducing the toxic side effects associated with administration of recombinant human (h)IL-12 protein while maintaining the ability to inhibit tumor growth and abolish tumor metastases in animal models. We have developed a more potent version of IL-12 by using DNA shuffling and screening to improve its ...
Steven R, Leong +5 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source
Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes
eLife, 2019 Genetic variation among orthologous proteins can cause cryptic phenotypic properties that only manifest in changing environments. Such variation may impact the evolvability of proteins, but the underlying molecular basis remains unclear.
Florian Baier +9 more
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Partitioning the fitness components of RNA populations evolving in vitro. [PDF]
PLoS ONE, 2013 All individuals in an evolving population compete for resources, and their performance is measured by a fitness metric. The performance of the individuals is relative to their abilities and to the biotic surroundings--the conditions under which they are ...
Carolina Díaz Arenas, Niles Lehman
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Origin of symbol-using systems: speech, but not sign, without the semantic urge [PDF]
, 2014 Natural language—spoken and signed—is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning.
Alberts B +27 more
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Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy +5 more
wiley +1 more source
Directed evolution and in silico analysis of reaction centre proteins reveal molecular signatures of photosynthesis adaptation to radiation pressure. [PDF]
PLoS ONE, 2011 Evolutionary mechanisms adopted by the photosynthetic apparatus to modifications in the Earth's atmosphere on a geological time-scale remain a focus of intense research.
Giuseppina Rea +8 more
doaj +1 more source
Surface-Directed Spinodal Decomposition: A Molecular Dynamics Study
, 2012 We use molecular dynamics (MD) simulations to study surface-directed spinodal decomposition (SDSD) in unstable binary ($AB$) fluid mixtures at wetting surfaces.
Das, Subir K. +2 more
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Transport of fullerene molecules along graphene nanoribbons [PDF]
, 2012 We study the motion of C60 fullerene molecules (buckyballs) and short-length carbon nanotubes on graphene nanoribbons. We demonstrate that the nanoribbon edge creates an effective potential that keeps the carbon structures on the surface.
Kivshar, Yuri S., Savin, Alexander V.
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