Results 231 to 240 of about 26,182 (278)

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

open access: yesChemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
The synthesis of betulinic acid and echinocystic acid saponins featuring QS‐21 minimal immunogenic motif is reported. These chimeric saponins, together with previously synthesized Lewis‐X‐containing triterpenoid saponins and a rhamnose‐modified saponin, were assessed for their toxicological and immunological profiles in wild‐type and/or hDC‐SIGN ...
Oscar Javier Gamboa Marin   +9 more
wiley   +1 more source

Structural Insights Into Galectin‐3 Recognition of a Selenoglycomimetic

open access: yesChemMedChem, Volume 20, Issue 10, May 19, 2025.
Galectin‐3, a β‐galactoside‐binding protein, plays a pivotal role in fibrosis and carcinogenesis. We explore the molecular recognition of a seleno‐digalactoside, modified with a benzyl group (SeDG‐Bn), as a potent Gal‐3 inhibitor. Using nuclear magnetic resonance and molecular dynamics simulations, we present a 3D model of the SeDG‐Bn/Gal‐3 complex ...
Maria Pia Lenza   +12 more
wiley   +1 more source

Valorization of Humins by Cyclic Levulinic Acid Production Using Polyoxometalates and Formic Acid

open access: yesChemSusChem, Volume 18, Issue 10, May 19, 2025.
In this work, a new catalytic route for the effective utilization of humin byproducts, enabling a cyclic synthesis of levulinic acid (LA) using formic acid (FA) as organocatalyst is proposed. Selective catalytic oxidation (SCO) of humins using the H5PV2Mo10O40 (HPA‐2) polyoxometalatecatalyst produces FA that can be isolated from the aqueous reaction ...
André Wassenberg   +4 more
wiley   +1 more source

The low FODMAP diet in adolescents functional abdominal in a non-guided setting: a prospective multicenter cohort study. [PDF]

open access: yesEur J Pediatr
Rexwinkel R   +10 more
europepmc   +1 more source

The Enteric Neuronal Circuitry: A Key Ignored Player in Nutrient Sensing Along the Gut–Brain Axis

open access: yesThe FASEB Journal, Volume 39, Issue 9, 15 May 2025.
The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. Despite its autonomous ability to execute local functions, its communication with the central nervous system is integral to the maintenance of homeostasis.
Ester Nikolla   +4 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, Volume 599, Issue 9, Page 1203-1221, May 2025.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Home - About - Disclaimer - Privacy