Results 141 to 150 of about 193,025 (292)

Financial Distress and Its Determinants in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease‐modifying therapies. Methods We identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the ...
Amber Brown Keebler, Yunju Im, Sofia Pedro, Ted R. Mikuls, Edward S. Peters, Kaleb Michaud   +5 more
wiley   +1 more source

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

MedComm
Biomedical research models are undergoing continuous evolution, while conventional models (two‐dimensional/ three‐dimensional cultures and animal studies) face limitations in physiological relevance and ethical constraints.
Xuxia Cao, Congmin Xia, Caifeng Li, Shiwen Deng, Junxian Cao, Hongjun Yang, Shaoping Wang, Peng Chen   +7 more
doaj   +1 more source

A critical appraisal of drug transport across the blood-brain barrier: Evaluation using new-age microfluidic technique

Brain Research Bulletin
Research over the past few decades has focused on elucidating the role of the blood-brain barrier (BBB) in neuroprotection, regulation of the brain microenvironment, and mediation of the selective permeability of substances, including drug molecules ...
Kiran Marathe, Dhruv Sanjay Gupta, Kalyani Barve, Dhananjay Bodas   +3 more
doaj   +1 more source

Translational Pharmacology [PDF]

, 2017
Alastair G. Stewart
core   +2 more sources

Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction [PDF]

BackgroundThe placental barrier is a critical interface that regulates drug transport between maternal and fetal circulation and is an important component in assessing fetal drug-exposure risk. Since pregnant women are often excluded from clinical trials,
Fei Wang, Jiao Zhang, Shiran Li, Siyu Zeng, Yong Yang, Yue Wu, Yujie Yang, Zhimin Li   +7 more
core   +1 more source

Testing a Personalized Approach to Chronic Low Back Pain: A Randomized Controlled Trial in Older Veterans

Arthritis Care &Research, EarlyView.
Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner, Angela Gentili, Meika A. Fang, Edward Garay, Laura Lawson, Lenore Joseph, Cathy C. Lee, Michelle I. Rossi, Beverly Thorn, Subashan Perera   +9 more
wiley   +1 more source

Organ-on-a-Chip Applications in Microfluidic Platforms

Micromachines
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication
Ling An, Yi Liu, Yaling Liu
doaj   +1 more source

Organ-on-Chip Technology for Aerobic Intestinal Host - Anaerobic Microbiota Research [PDF]

, 2021
Bossink, Elsbeth G.B.M., Odijk, Mathieu, Segerink, Loes   +2 more
core   +2 more sources

Animal Experimentation: Working Towards a Paradigm Change [PDF]

, 2019
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans.
Herrmann, Kathrin, (ed.), Jayne, Kimberley, (ed.)   +1 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, Accepted Article.
Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, In collaboration with the Consensus Expert Panel (CEP) members   +19 more
wiley   +1 more source