Results 51 to 60 of about 193,025 (292)

Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation.

open access: yesLab on a Chip, 2022
Coronavirus disease 2019 (COVID-19) was primarily identified as a novel disease causing acute respiratory syndrome. However, as the pandemic progressed various cases of secondary organ infection and damage by severe respiratory syndrome coronavirus 2 ...
R. Lu   +11 more
semanticscholar   +1 more source

Numerical modeling of the fiber deposition flow in extrusion-based 3D bioprinting [PDF]

open access: yes, 2021
Extrusion bioprinting involves the deposition of bioinks in a layer-wise fashion to build 3D structures that mimic natural living systems\u27 behavior in tissue engineering. Hydrogels are the most common bioinks, in which their viscosity properties are
Talluri, Dhanvanth Jaya
core   +1 more source

Multi-Omics for the Understanding of Brain Diseases [PDF]

open access: yes, 2022
Omics technologies such as proteomics, genomics, and metabolomics are widely applied for the identification and characterization of new molecular signatures. However, molecular profiling that makes it possible to understand neurodegenerative diseases has

core   +1 more source

A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles

open access: yesJournal of Extracellular Vesicles, 2022
Mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs) show therapeutic potential in multiple disease models, including kidney injury.
Vivian V T Nguyen   +13 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Pancreatic islet organoids-on-a-chip: how far have we gone?

open access: yesJournal of Nanobiotechnology, 2022
Diabetes mellitus (DM) is a disease caused by dysfunction or disruption of pancreatic islets. The advent and development of microfluidic organoids-on-a-chip platforms have facilitated reproduce of complex and dynamic environment for tissue or organ ...
Jiaxiang Yin   +5 more
doaj   +1 more source

Lab on a Chip: Conquer Disease at the Earliest

open access: yesJournal of Pharmacy and Bioallied Sciences, 2018
Oral cancer is the fifth most common cancer in the world, accounting for numerous deaths annually. The 5-year survival rate remains approximately 50% for oral squamous cell carcinoma (OSCC) in the past several decades.
G. Daniel   +3 more
semanticscholar   +1 more source

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs.

open access: yesJournal of Visualized Experiments, 2023
The high prevalence of debilitating joint diseases like osteoarthritis (OA) poses a high socioeconomic burden. Currently, the available drugs that target joint disorders are mostly palliative.
Meagan J. Makarcyzk   +13 more
semanticscholar   +1 more source

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures [PDF]

open access: yes, 2020
Recent meta-analyses of genome-wide association studies identified a number of genetic risk factors of Alzheimer’s disease; however, little is known about the mechanisms by which they contribute to the pathological process. As synapse loss is observed at
Amouyel, Philippe   +14 more
core   +1 more source

Micro/nanofluidic and lab-on-a-chip devices for biomedical applications [PDF]

open access: yes, 2022
Micro/Nanofluidic and lab-on-a-chip devices have been increasingly used in biomedical research [1]. Because of their adaptability, feasibility, and cost-efficiency, these devices can revolutionize the future of preclinical technologies.
Carvalho, Violeta   +2 more
core   +1 more source

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