Results 51 to 60 of about 192,797 (169)

Microfluidic platforms for the manipulation of cells and particles

Talanta Open, 2022
The vast majority of researches in cell biology, biomedicine, biotechnology, and chemistry require cell/particle separation from a pool of samples for disease diagnostics and clinical applications.
Hadi Afsaneh, Rasool Mohammadi
doaj   +1 more source

Osteopontin stabilization and collagen containment slows amorphous calcium phosphate transformation during human aortic valve leaflet calcification. [PDF]

Calcification of aortic valve leaflets is a growing mortality threat for the 18 million human lives claimed globally each year by heart disease. Extensive research has focused on the cellular and molecular pathophysiology associated with calcification ...
Ajijola, Olujimi, Bhargava, Rohit, Fouke, Bruce, Fouke, Kyle, Mori, Shumpei, Samuel, Ashok, Shivkumar, Kalyanam, Sivaguru, Mayandi   +7 more
core   +1 more source

Two-Dimensional (2D) Nanosilicates for Additive Manufacturing: Ink, Support-Bath and Sacrificial Ink [PDF]

, 2021
The growing need for tissue and organ replacements has resulted in significant increase in the gap between the organ donors and patients on the waitlist.
Rajput, Satyam
core  

Gut-on-a-chip for disease models

Journal of Tissue Engineering, 2023
The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be ...
Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li   +3 more
doaj   +1 more source

Microfluidic platform for understanding Parkinson’s disease and α-synuclein conformation

Translational Neurodegeneration
Microfluidic systems are an innovative engineering solution that is increasingly being used in a wide range of scientific fields. These systems use fluids in microchannels (1 to 300 microns) to analyze extremely small volumes of sample and reagent ...
Tregub Pavel, Zembatov Georgy, Namiot Eugenia, Kolotyeva Natalia, Yurchenko Stanislav, Illarioshkin Sergey, Salmina Alla   +6 more
doaj   +1 more source

Progress in the Application of Organoids-On-A-Chip in Diseases

Organogenesis
With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development.
Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong   +6 more
doaj   +1 more source

The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) affects millions of people worldwide, but there are limited drugs available to treat it, so acquiring a more comprehensive comprehension of the underlying reasons and mechanisms behind inflammation is crucial, as well as ...
Xin Zhang, Xin Zhang, Xin Zhang, Rui Su, Rui Su, Rui Su, Hui Wang, Hui Wang, Hui Wang, Ruihe Wu, Ruihe Wu, Ruihe Wu, Yuxin Fan, Yuxin Fan, Yuxin Fan, Zexuan Bin, Zexuan Bin, Zexuan Bin, Chong Gao, Caihong Wang, Caihong Wang, Caihong Wang   +21 more
doaj   +1 more source

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

Gut Microbes, 2020
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin, Landon A. Hackley, Hyun Jung Kim   +2 more
doaj   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science
The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions.
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
doaj   +1 more source

Perspectives on organ-on-a-chip technology for natural products evaluation

Food & Medicine Homology
Natural products have always been a treasure trove for clinical drug development and a source of inspiration for lead compounds in the process of new drug discovery.
Xin Wang, Yu-Hang Miao, Xiao-Min Zhao, Xin Liu, Yan-Wei Hu, Da-Wei Deng   +5 more
doaj   +1 more source