Results 61 to 70 of about 193,025 (292)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Lab on a Chip, 2022 Podocytes, localized in the glomerulus, are a prognostic factor of proteinuria in kidney disease and are exposed to distinct physiological stimuli from basal to apical filtration flow.
Kotaro Doi +12 more
semanticscholar +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A novel vascularized urethra-on-a-chip model
Scientific ReportsThe male urethra transports urine and semen. Any disease of the male urethra, hindering normal voiding or ejaculation, has a major impact on quality of life. Urethral stricture disease is common and molecular research into urethral strictures is hampered
Aina Casademont-Roca +5 more
doaj +1 more source
Neuromuscular disease modeling on a chip
Disease Models & Mechanisms, 2020 Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to engineer cells into microscale tissues with native-like features and then extract physiologically relevant readouts at scale.
Jeffrey W. Santoso, Megan L. McCain
doaj +1 more source
ACS Sensors, 2022 Over the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (
M. Mir +4 more
semanticscholar +1 more source
Survey on prediction, classification and tracking of neurodegenerative diseases [PDF]
Neurodegenerative diseases (NDD) such as Alzheimer's, Parkinson's, and Huntington's disease are complex conditions that progressively impair neurological function.
Dhavalgi, Veena, Ranganatha, H R
core +2 more sources
3D organotypic cell structures for drug development and Microorganism-Host interaction research [PDF]
, 2021 The article describes a new method of tissue engineering, which is based on the use of three-dimensional multicellular constructs consisting of stem cells that mimic the native tissue in vivo ...
Avtina, T. V. +5 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Bioprinting of three-dimensional culture models and organ-on-a-chip systems [PDF]
, 2017 Multimaterial bioprinting technologies offer promising avenues to create mini-organ models with enhanced tissue heterogeneity and complexity. This article focuses on the application of three-dimensional bioprinting to fabricate organ-on-a-chip systems ...
Huang, YYS, Liu, Y, Zhang, D
core +1 more source