Results 61 to 70 of about 192,797 (169)
Modeling Human Brain Circuitry Using Pluripotent Stem Cell Platforms [PDF]
, 2019 Neural circuits are the underlying functional units of the human brain that govern complex behavior and higher-order cognitive processes. Disruptions in neural circuit development have been implicated in the pathogenesis of multiple neurodevelopmental ...
Annalisa M. Hartlaub +3 more
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Micromachines, 2020 The human circulatory system is divided into two complementary and different systems, the cardiovascular and the lymphatic system. The cardiovascular system is mainly concerned with providing nutrients to the body via blood and transporting wastes away ...
Aria R. Henderson +2 more
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Frontiers in Neurology, 2018 Alzheimer's disease (AD) is an irreversible neurodegenerative illness and the exact etiology of the disease remains unknown. It is characterized by long preclinical and prodromal phases with pathological features including an accumulation of amyloid-beta
Heejung Chun +7 more
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Skeletal MuscleBackground Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. However, due to the inherent genetic heterogeneity among human individuals, it is often difficult to distinguish disease ...
Stijn L. M. in ‘t Groen +5 more
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Lab-on-a-Chip Platforms for Detection of Cardiovascular Disease and Cancer Biomarkers
Sensors, 2017 Cardiovascular disease (CVD) and cancer are two leading causes of death worldwide. CVD and cancer share risk factors such as obesity and diabetes mellitus and have common diagnostic biomarkers such as interleukin-6 and C-reactive protein.
Jiandong Wu +5 more
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Application and prospects of lung organ-on-a-chip in the development of new drugs
BioMedical Engineering OnLineRespiratory disease, such as lung cancer, is a major risk factor that seriously endangers human health. In the development of new drugs, conventional preclinical and clinical testing stages rely on cell culture and animal experiment.
Jun Su +5 more
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Laser-processed parchment paper for fabrication of chronic wound dressings with selective oxygenation [PDF]
, 2016 Chronic non-healing wounds (e.g., diabetic foot ulcers and bed sores) impact over 6.5 million Americans per year, costs in excess of $25 billion to treat on an annual basis, and are on the rise due to increasing levels of obesity and diabetes compounded ...
Ochoa, Manuel
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Construction of in vitro liver-on-a-chip models and application progress
BioMedical Engineering OnLineThe liver is the largest internal organ of the human body. It has a complex structure and function and plays a vital role in drug metabolism. In recent decades, extensive research has aimed to develop in vitro models that can simulate liver function to ...
Jie Liu +5 more
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Bone-on-a-Chip Systems for Hematological Cancers
BiosensorsHematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, and myeloma, which necessitate the use of a distinct chemotherapeutic approach.
Gül Kozalak, Ali Koşar
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Entwicklung von mikrofluidischen Multi-Organ-Zellchipsystemen für die in vitro Metabolisierung und Bestimmung der Toxizität von Substanzen [PDF]
, 2018 Die Entwicklung neuer Arzneistoffe ist ein langer und kostenintensiver Prozess. Verlässliche experimentelle Modelle zur präklinischen Testung während frühen Phasen der Arzneistoffentwicklung sind essenziell, um einem späteren Misserfolg vorzubeugen ...
Theobald, Jannick Florian
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