Results 71 to 80 of about 193,025 (292)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip

Frontiers in Cell and Developmental Biology, 2022
Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology.
Bolin Jing, K. Xia, Chen Zhang, Siming Jiao, Limeng Zhu, Jinhua Wei, Zhuo A. Wang, Nannan Chen, P. Tu, J. Li, Yuguang Du   +10 more
semanticscholar   +1 more source

IMMUNITY-ON-A-CHIP Microfluidic Devices for Immunoengineering [PDF]

, 2017
Immunitet-på-mikrobrikke Mikrofluidiske innretninger for immunologisk forskning og utvikling Sammendrag: Det siste tiåret har mikrofluidteknologi, dvs væskestrømmer i mikroskala basert på prosesser fra halvlederindustrien, gitt et betydelig løfte om ...
Moura Rosa, Patrícia
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

Viruses, 2022
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS).
Niloufar A. Boghdeh, Kenneth H. Risner, Michael D Barrera, Clayton M. Britt, D. Schaffer, Farhang Alem, Jacquelyn A. Brown, J. Wikswo, Aarthi Narayanan   +8 more
semanticscholar   +1 more source

Two-Dimensional (2D) Nanosilicates for Additive Manufacturing: Ink, Support-Bath and Sacrificial Ink [PDF]

, 2021
The growing need for tissue and organ replacements has resulted in significant increase in the gap between the organ donors and patients on the waitlist.
Rajput, Satyam
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Current Advances and Future Perspectives of Liver-on-a-Chip Platforms Incorporating Dynamic Fluid Flow

Biomimetics
The liver is a vital organ responsible for a broad range of metabolic functions, including glucose and lipid metabolism, detoxification, and protein synthesis.
Jingyeong Yun, Tae-Joon Jeon, Sun Min Kim   +2 more
doaj   +1 more source

Microfluidic platforms for the manipulation of cells and particles

Talanta Open, 2022
The vast majority of researches in cell biology, biomedicine, biotechnology, and chemistry require cell/particle separation from a pool of samples for disease diagnostics and clinical applications.
Hadi Afsaneh, Rasool Mohammadi
doaj   +1 more source