Results 81 to 90 of about 193,025 (292)

Training‐on‐a‐Chip: A Multi‐Organ Device to Study the Effect of Muscle Exercise on Insulin Secretion in Vitro

Advanced Materials & Technologies, 2022
Organ‐on‐a‐chip (OOC) devices bring innovative disease modeling and drug discovery approaches by providing biomimetic models of tissues and organs in vitro combined with biosensors.
J. Fernández‐Costa, M. A. Ortega, Júlia Rodríguez‐Comas, G. López-Muñoz, J. Yeste, Lluís Mangas‐Florencio, Míriam Fernandez‐González, Eduard Martin‐Lasierra, A. Tejedera-Villafranca, J. Ramón‐Azcón   +9 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Vasculature-On-A-Chip for In Vitro Disease Models

Bioengineering, 2017
Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial ...
Seunggyu Kim, Wanho Kim, Seongjin Lim, Jessie S. Jeon   +3 more
doaj   +1 more source

Gut-on-a-chip for disease models

Journal of Tissue Engineering, 2023
The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be ...
Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li   +3 more
doaj   +1 more source

High-throughput 3D microvessel-on-a-chip model to study defective angiogenesis in systemic sclerosis

Scientific Reports, 2022
In early systemic sclerosis (Scleroderma, SSc), the vasculature is impaired. Although the exact etiology of endothelial cell damage in SSc remains unclear, it is hypothesized that endothelial to mesenchymal transition (EndoMT) plays a key role.
B. Kramer, C. Corallo, A. van den Heuvel, Justin D Crawford, T. Olivier, Edo D Elstak, N. Giordano, P. Vulto, H. Lanz, R. Janssen, Michela A. Tessari   +10 more
semanticscholar   +1 more source

Osteopontin stabilization and collagen containment slows amorphous calcium phosphate transformation during human aortic valve leaflet calcification. [PDF]

Calcification of aortic valve leaflets is a growing mortality threat for the 18 million human lives claimed globally each year by heart disease. Extensive research has focused on the cellular and molecular pathophysiology associated with calcification ...
Ajijola, Olujimi, Bhargava, Rohit, Fouke, Bruce, Fouke, Kyle, Mori, Shumpei, Samuel, Ashok, Shivkumar, Kalyanam, Sivaguru, Mayandi   +7 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Microfluidic platform for understanding Parkinson’s disease and α-synuclein conformation

Translational Neurodegeneration
Microfluidic systems are an innovative engineering solution that is increasingly being used in a wide range of scientific fields. These systems use fluids in microchannels (1 to 300 microns) to analyze extremely small volumes of sample and reagent ...
Tregub Pavel, Zembatov Georgy, Namiot Eugenia, Kolotyeva Natalia, Yurchenko Stanislav, Illarioshkin Sergey, Salmina Alla   +6 more
doaj   +1 more source

Progress in the Application of Organoids-On-A-Chip in Diseases

Organogenesis
With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development.
Qiao Geng, Yanyan Xu, Yang Hu, Lu Wang, Yi Wang, Zhimin Fan, Desong Kong   +6 more
doaj   +1 more source