Results 81 to 90 of about 192,797 (169)

Animal Experimentation: Working Towards a Paradigm Change [PDF]

, 2019
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans.
Herrmann, Kathrin, (ed.), Jayne, Kimberley, (ed.)   +1 more
core   +1 more source

Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction [PDF]

BackgroundThe placental barrier is a critical interface that regulates drug transport between maternal and fetal circulation and is an important component in assessing fetal drug-exposure risk. Since pregnant women are often excluded from clinical trials,
Fei Wang, Jiao Zhang, Shiran Li, Siyu Zeng, Yong Yang, Yue Wu, Yujie Yang, Zhimin Li   +7 more
core   +1 more source

Organ-on-a-Chip Applications in Microfluidic Platforms

Micromachines
Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research and drug discovery. This article reviews the design and fabrication
Ling An, Yi Liu, Yaling Liu
doaj   +1 more source

Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells. [PDF]

Sci Rep, 2020
Armistead FJ, Gala De Pablo J, Gadêlha H, Peyman SA, Evans SD.   +4 more
europepmc   +1 more source

CRISPR in 3D: Innovations in Disease Modelling and Personalized Medicine

BioTechniques
The CRISPR-Cas system of genetic engineering has had a significant impact on science and society since its advent in 2013. CRISPR integration with 3D culture systems such as organ-on-a-chips, as well as fast emerging commercial technologies, has ...
Louis J Gautier
doaj   +1 more source

Exploring microorganism–host interactions: Emerging organoid models and analytical approaches

mLife
Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in
Yue Shi, Min Xu, Yanhong Huang, Jing Qu, Shumin Liao, Yingzi Liu, Liang Li   +6 more
doaj   +1 more source

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains [PDF]

, 2016

core   +1 more source

Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis

Frontiers in Immunology
IntroductionArthritis, a disease affecting over 50 million adults in the United States, encompasses many different conditions involving joints and surrounding tissues.
Kyra W. Y. Smith, Kyra W. Y. Smith, Stephanie L. Fung, Hsin-Fang Wu, Hsin-Fang Wu, Irene Chiesa, Irene Chiesa, Giovanni Vozzi, Carmelo De Maria, Riccardo Gottardi, Riccardo Gottardi, Riccardo Gottardi, Riccardo Gottardi, Riccardo Gottardi, Riccardo Gottardi   +14 more
doaj   +1 more source

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

Frontiers in Toxicology
The use of Heated Tobacco Products (HTPs) is expected to have a reduced-risk potential for cardiovascular disease, including atherosclerosis, compared with combustible cigarettes (CCs) Because of the complex relationship between atherosclerosis and ...
Ayaka Hayashida, Atsuko Nozawa, Shigeaki Ito   +2 more
doaj   +1 more source

Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling

Journal of Translational Medicine
Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately ...
Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao, Yu Chen   +6 more
doaj   +1 more source