Results 11 to 20 of about 1,230,509 (271)

Modeling Human Disease [PDF]

Science, 2012
The astonishing recent advances in the technology for determining DNA sequences have made personalized genomics a foreseeable reality for the doctor's office. This technology has started a whole new gold rush for human disease gene discovery and produced an onslaught of information that represents a new challenge in personalized medicine: connecting ...
Aaron D, Gitler, Ruth, Lehmann
openaire   +2 more sources

A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

Cell & Bioscience, 2023
Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee, Yulong Fu, Jun-yi Zhu, Pei Wen, Joyce van de Leemput, Patricio E. Ray, Zhe Han   +6 more
doaj   +1 more source

3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases

Biomedicines, 2022
The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race.
Shirley Pei Shan Chia, Sharleen Li Ying Kong, Jeremy Kah Sheng Pang, Boon-Seng Soh   +3 more
doaj   +1 more source

Enhanced vaccine control of epidemics in adaptive networks [PDF]

, 2009
We study vaccine control for disease spread on an adaptive network modeling disease avoidance behavior. Control is implemented by adding Poisson distributed vaccination of susceptibles.
Ira B. Schwartz, Leah B. Shaw, M. J. Keeling, M. S. Bartlett, R. M. Anderson   +4 more
core   +3 more sources

Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study

BMC Infectious Diseases, 2018
Background Malaria transmission is both seasonal and heterogeneous, and mathematical models that seek to predict the effects of possible intervention strategies should accurately capture realistic seasonality of vector abundance, seasonal dynamics of ...
Prashanth Selvaraj, Edward A. Wenger, Jaline Gerardin   +2 more
doaj   +1 more source

Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration

Journal of Translational Medicine, 2021
The skin is made up of a plethora of cells arranged in multiple layers with complex and intricate vascular networks, creating a dynamic microenvironment of cells-to-matrix interactions.
Qian Hua Phua, Hua Alexander Han, Boon-Seng Soh   +2 more
doaj   +1 more source

Evaluating COVID-19 reporting data in the context of testing strategies across 31 low- and middle-income countries

International Journal of Infectious Diseases, 2021
: Background: The case count for coronavirus disease 2019 (COVID-19) is the predominant measure used to track epidemiological dynamics and inform policy decision-making.
Mollie M. Van Gordon, Kevin A. McCarthy, Joshua L. Proctor, Brittany L. Hagedorn   +3 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

Journal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu, Chen Liu, Xiaohu Huang, Joyce van de Leemput, Hangnoh Lee, Zhe Han   +5 more
doaj   +1 more source

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha,, Frohnert, Brigitte I.,, Ghosh, Soumya,, Kwon, Bum Chul,, Lund University., Lund University., Lundgren, Markus,, Ng, Kenney,, Severson, Kristen A.,, Sun, Zhaonan,   +9 more
core   +1 more source

Edge-Based Compartmental Modeling for Infectious Disease Spread Part III: Disease and Population Structure [PDF]

, 2011
We consider the edge-based compartmental models for infectious disease spread introduced in Part I. These models allow us to consider standard SIR diseases spreading in random populations.
Alain Barrat, C Bauch, C Pilcher, E Volz, EM Volz, Erik M. Volz, F Ball, F Ball, F Ball, F Ball, J Lindquist, J Parsons, J Wallinga, JC Miller, JC Miller, JC Miller, JC Miller, JC Miller, JC Miller, JO Lloyd-Smith, Joel C. Miller, K Dietz, K Dietz, K Eames, K Eames, K Sharkey, L Decreusefond, LA Meyers, M Altmann, M Molloy, MEJ Newman, MEJ Newman, O Diekmann, R Pastor-Satorras, RM May, RM May, T House, T House, Y Moreno   +38 more
core   +2 more sources