Results 21 to 30 of about 1,230,509 (271)

Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Malaria Journal, 2017
Background Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised ...
Jaline Gerardin, Caitlin A. Bever, Daniel Bridenbecker, Busiku Hamainza, Kafula Silumbe, John M. Miller, Thomas P. Eisele, Philip A. Eckhoff, Edward A. Wenger   +8 more
doaj   +1 more source

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]

, 2011
The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver, David Henderson, Jonathan Derry, Jonathan Derry, Jonathan Izant, Lara Mangravite, Matt Furia, Michael Kellen, Solveig Sieberts, Stephen Friend, Xavier Schildwachter   +10 more
core   +2 more sources

Sub-national levels and trends in contraceptive prevalence, unmet need, and demand for family planning in Nigeria with survey uncertainty

BMC Public Health, 2019
Background Ambitious global goals have been established to provide universal access to affordable modern contraceptive methods. To measure progress toward such goals in populous countries like Nigeria, it’s essential to characterize the current levels ...
Laina D. Mercer, Fred Lu, Joshua L. Proctor   +2 more
doaj   +1 more source

Mending a broken heart: current strategies and limitations of cell-based therapy

Stem Cell Research & Therapy, 2020
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the
Lee Chuen Liew, Beatrice Xuan Ho, Boon-Seng Soh   +2 more
doaj   +1 more source

Preventing a cluster from becoming a new wave in settings with zero community COVID-19 cases

BMC Infectious Diseases, 2022
Background In settings with zero community transmission, any new SARS-CoV-2 outbreaks are likely to be the result of random incursions. The level of restrictions in place at the time of the incursion is likely to considerably affect possible outbreak ...
Romesh G. Abeysuriya, Dominic Delport, Robyn M. Stuart, Rachel Sacks-Davis, Cliff C. Kerr, Dina Mistry, Daniel J. Klein, Margaret Hellard, Nick Scott   +8 more
doaj   +1 more source

Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

BMC Medicine, 2023
Background Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous study not to be cost-effective in ...
Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo, Mark Jit   +9 more
doaj   +1 more source

Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns [version 2; peer review: 2 approved]

Gates Open Research, 2022
Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services.
Brittany Hagedorn, Kurt Frey, Susan Annemarie Wang, Kevin A. McCarthy, Raymond Hutubessy   +4 more
doaj   +1 more source

Disease modeling using Evolved Discriminate Function [PDF]

, 2003
Precocious diagnosis increases the survival time and patient quality of life. It is a binary classification, exhaustively studied in the literature. This paper innovates proposing the application of genetic programming to obtain a discriminate function ...
Kalganova, T, Werner, JC
core   +2 more sources

A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features

Human Genomics, 2018
Background Intellectual disability (ID) is a common condition with a population prevalence frequency of 1–3% and an enrichment for males, driven in part by the contribution of mutant alleles on the X-chromosome.
Georgios Kellaris, Kamal Khan, Shahid M. Baig, I-Chun Tsai, Francisca Millan Zamora, Paul Ruggieri, Marvin R. Natowicz, Nicholas Katsanis   +7 more
doaj   +1 more source

Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome

Human Genomics, 2017
Background The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this
Benjamin M. Helm, Jason R. Willer, Azita Sadeghpour, Christelle Golzio, Eric Crouch, Samantha Schrier Vergano, Nicholas Katsanis, Erica E. Davis   +7 more
doaj   +1 more source