Results 131 to 140 of about 1,905,801 (316)
Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance [PDF]
, 2012 Glial cells in Alzheimer’s disease (AD) have been shown to be capable of clearing or at least restricting the accumulation of toxic amyloid beta (Aβ) deposits.
Jari Koistinaho +2 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
An economic approach to collective management of endemic animal diseases [PDF]
The control of animal diseases is an issue of particular interest in animal production chains. Because of their direct impact on production, animal diseases generate income shortfalls for farmers.
Krebs, Stephane, Rat-Aspert, Olivier
core +1 more source
The Cambridge MRI database for animal models of Huntington disease. [PDF]
, 2015 We describe the Cambridge animal brain magnetic resonance imaging repository comprising 400 datasets to date from mouse models of Huntington disease.
Morton, A Jennifer, Sawiak, Stephen J
core +2 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans
Molecules, 2017 Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, and the target of immunosuppressive agent tacrolimus (TAC).
Yanli Wang +3 more
doaj +1 more source
New Methods for Integrated Models of Animal Disease Control [PDF]
Accurate assessments of the epidemiological and economic impacts of an animal disease require the incorporation of feedbacks between disease spread and production incentives. This paper motivates a new modeling framework that is sensitive to the dynamics
Rich, Karl M.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Flu‐CED: A comparative transcriptomics database of influenza virus‐infected human and animal models
Animal Models and Experimental MedicineBackground The continuing emergence of influenza virus has highlighted the value of public databases and related bioinformatic analysis tools in investigating transcriptomic change caused by different influenza virus infections in human and animal models.
Yue Wu +7 more
doaj +1 more source