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Animal models of Cushing's disease
Trends in Endocrinology & Metabolism, 1994Cushing's disease, defined as hyperadrenocorticism resulting from excessive secretion of pituitary ACTH, occurs spontaneously and quite commonly in dogs and horses. In dogs, as in humans, the disease is usually associated with a small tumor of the pituitary pars distalis.
R J, Kemppainen, M, E Peterson
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Parkinson's disease: animal models
2007Publisher Summary Animal models are an essential tool to study human diseases, not only to enable a thorough investigation into the mechanisms involved in the pathogenesis of a disease but also to help in the development of therapeutic strategies. This chapter describes genetic as well as pharmacological manipulations used to develop animal models ...
Ranjita, Betarbet, J Timothy, Greenamyre
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Polycystic Ovarian Disease: Animal Models
Endocrinology and Metabolism Clinics of North America, 1988The reproductive systems of human beings and other vertebrates are grossly similar. In the ovary particularly, the biochemical and physiologic processes are identical not only in the formation of germ cells, the development of primordial follicles and their subsequent growth to Graafian follicles, and eventual ovulation but also in anatomic structure ...
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Animal models of Wilson disease
2017Wilson disease (WD) is caused by ATPase copper-transporting beta (ATP7B) mutations and results in copper toxicity in liver and brain. Although the defective gene was identified in 1993, the specific mechanisms underlying copper toxicity and the remarkable phenotypic diversity of the disease are still poorly understood.
Valentina, Medici, Dominik, Huster
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Animal Models of Neurodegenerative Diseases
2009Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington's disease and Parkinson's disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in ...
Wendy, Phillips +3 more
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Animal Models of Neurological Disease
2010The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology.
Amol, Shah +4 more
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