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Deciphering the Enigma of Calcific Aortic Valve Disease: The Pivotal Role of Animal Models in Unraveling Pathogenesis and Advancing Therapeutic Strategies. [PDF]

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Animal models of Cushing's disease

Trends in Endocrinology & Metabolism, 1994
Cushing's disease, defined as hyperadrenocorticism resulting from excessive secretion of pituitary ACTH, occurs spontaneously and quite commonly in dogs and horses. In dogs, as in humans, the disease is usually associated with a small tumor of the pituitary pars distalis.
R J, Kemppainen, M, E Peterson
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Animal Models of Neurodegenerative Diseases

2009
Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington's disease and Parkinson's disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in ...
Wendy, Phillips   +3 more
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Animal models of Wilson disease

2017
Wilson disease (WD) is caused by ATPase copper-transporting beta (ATP7B) mutations and results in copper toxicity in liver and brain. Although the defective gene was identified in 1993, the specific mechanisms underlying copper toxicity and the remarkable phenotypic diversity of the disease are still poorly understood.
Valentina, Medici, Dominik, Huster
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Animal models of Parkinson's disease

BioEssays, 2002
AbstractAnimal models are important tools in experimental medical science to better understand pathogenesis of human diseases. Once developed, these models can be exploited to test therapeutic approaches for treating functional disturbances observed in the disease of interest. On the basis of experimental and clinical findings, Parkinson's disease (PD)
Ranjita, Betarbet   +2 more
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Animal Models for Human Diseases

Perspectives in Biology and Medicine, 1982
The use of animal models for the study of human disease is for the most part a recent development. This discussion of the use of animal models for human diseases directs attention to the sterile period early advances some personal experiences the human as the model biological oddities among common laboratory animals malignancies in laboratory animals ...
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Animal Models of Neurological Disease

2010
The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology.
Amol, Shah   +4 more
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