Results 181 to 190 of about 3,031,744 (313)

The engineered Immunoprotein enhance broad-spectrum disease resistance in solanaceous crops. [PDF]

BMC Plant Biol
Huang Y, Li L, Wei L, Yang X, Zeng S, Zhang T, Li Y, Shen X, He Z, Liu J, Shen J, Cai Y.   +11 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Systemic stomatal immunity: the beacon of fire and smoke in plant disease resistance. [PDF]

Adv Biotechnol (Singap)
Liu C, Yu Q, Song S, Qi T.
europepmc   +1 more source

Resistance to Malignant Disease [PDF]

BMJ, 1946
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Signaling Pathway Analysis and Downstream Genes Associated with Disease Resistance Mediated by GmSRC7. [PDF]

Plants (Basel)
Li A, Yao C, Yan T, Hao X, Geng D, Zhang Q, Li H, Bao W, Bai Y.   +8 more
europepmc   +1 more source

Disease Resistance In Cabbage [PDF]

Proceedings of the National Academy of Sciences, 1918
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genome editing and regeneration pipeline for engineering disease resistance in tomato using CRISPR/Cas9. [PDF]

Front Plant Sci
Erdoğan İ, Debbarma R, Sherry M, Mancak İ, Grant M, Tör M.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source