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How Everything Is Connected to Everything Else – Population‐Specific Connections between Adaptive Evolution, Disease Susceptibility, and Drug Responsiveness [PDF]

Advanced Genetics
The genome is like a kaleidoscope through which researchers have obtained varied findings, including favored mutations, disease susceptibility sites, and drug‐responsive sites.
Ji Tang, Hao Zhu
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Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine

Acta Materia Medica, 2022
Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes.
Jie Sun, Chang-Yu Yan, Jie Niu, Ming-Hai Pan, Zhuo Luo, Wen-Jun Duan, Wen Li, Yan-Ping Wu, Wan-Yang Sun, Feng Huang, Fan-Na Liu, Hai-Zhi Liu, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +14 more
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Potential of Tamarind Shell Extract against Oxidative Stress In Vivo and In Vitro

Molecules, 2023
Tamarind shell is rich in flavonoids and exhibits good biological activities. In this study, we aimed to analyze the chemical composition of tamarind shell extract (TSE), and to investigate antioxidant capacity of TSE in vitro and in vivo.
Weixi Li, Rongping Huang, Shaocong Han, Xiyou Li, Haibiao Gong, Qiongyi Zhang, Changyu Yan, Yifang Li, Rongrong He   +8 more
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Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models

Foods, 2023
Alcohol liver disease (ALD) is one of the leading outcomes of acute and chronic liver injury. Accumulative evidence has confirmed that oxidative stress is involved in the development of ALD.
Shao-Cong Han, Rong-Ping Huang, Qiong-Yi Zhang, Chang-Yu Yan, Xi-You Li, Yi-Fang Li, Rong-Rong He, Wei-Xi Li   +7 more
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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Signal Transduction and Targeted Therapy, 2022
Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death.
Xiao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu, Wan-Yang Sun, Wen-Jun Duan, Guan Wang, Hiroshi Kurihara, Rong-Rong He, Yi-Fang Li, Yang Chen, Hongcai Shang   +10 more
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A ferroptosis-targeting ceria anchored halloysite as orally drug delivery system for radiation colitis therapy

Nature Communications, 2023
Radiation colitis is the leading cause of diarrhea and hematochezia in pelvic radiotherapy patients. This work advances the pathogenesis of radiation colitis from the perspective of ferroptosis.
Yue Feng, Xiang Luo, Zichun Li, Xinjuan Fan, Yiting Wang, Rong-Rong He, Mingxian Liu   +6 more
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ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis

Pharmacological Research, 2023
Oxidative disruption of dopaminergic neurons is regarded as a crucial pathogenesis in Parkinson's disease (PD), eventually causing neurodegenerative progression.
Kun Li, Meng Wang, Zi-Han Huang, Min Wang, Wan-Yang Sun, Hiroshi Kurihara, Rui-Ting Huang, Rong Wang, Feng Huang, Lei Liang, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He   +12 more
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GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Journal of Advanced Research, 2023
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by oxidative stress that triggers motor neurons loss in the brain and spinal cord.
Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +17 more
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Phospholipid peroxidation-driven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development

Redox Biology, 2022
Maternal stress has been associated with poor birth outcomes, including preterm birth, infant mortality, and low birth weight. Bone development disorders in the embryo as a result of maternal stress are believed to be mediated through oxidative stress ...
Jie Niu, Xin Wan, Gui-Yuan Yu, Shan Jiang, Ruo-Nan Yi, Yan-Ping Wu, Shu-Hua Ouyang, Lei Liang, Hiroshi Kurihara, Wan-Yang Sun, Xiao-Feng Zhu, Rong-Hua Zhang, Yun-Feng Cao, Jian-Bo He, Wen-Jun Duan, Yi-Fang Li, Rong-Rong He   +16 more
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Applying multi-omics data to study the genetic background of bovine respiratory disease infection in feedlot crossbred cattle

Frontiers in Genetics, 2022
Bovine respiratory disease (BRD) is the most common and costly infectious disease affecting the wellbeing and productivity of beef cattle in North America. BRD is a complex disease whose development is dependent on environmental factors and host genetics.
Jiyuan Li, Robert Mukiibi, Janelle Jiminez, Zhiquan Wang, Everestus C. Akanno, Edouard Timsit, Graham S. Plastow   +6 more
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