Results 11 to 20 of about 692,625 (254)

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy [PDF]

, 2012
Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
A Lionikas, AD Ebert, B Wirth, BJ Turner, C Cifuentes-Diaz, Chantal A. Mutsaers, CL Lorson, CM McCann, CM Mutsaers, CS Lobsiger, D Angaut-Petit, Derek Thomson, G Feng, G Valdez, G Vrbova, Gillian Hamilton, GZ Mentis, H Ilieva, Huaibin Cai, J Hegedus, J Pearn, JN Sleigh, Joya E. Nahon, K Talbot, KK Ling, KK Ling, L Kong, LM Murray, LM Murray, LM Murray, LR Fischer, M Ruggui, MC Brown, MR Lunn, R Dengler, S Kariya, S Kariya, S Lefebvre, S Pun, S Saxena, Simon H. Parson, Sophie R. Thomson, SR Thomson, T Yamazaki, TH Gillingwater, Thomas H. Gillingwater, UR Monani, WG Bradley, Z Feng   +48 more
core   +18 more sources

Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years [PDF]

, 2005
Introduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives.
Bansi DS, C. Brückl, C. Folwaczny, Cambridge G, Colombel JF, Folwaczny C, Folwaczny C, Folwaczny C, Folwaczny C, Glas J, H.C. Hollay, H.P. Török, Hoffman IE, J. Glas, Klebl FH, Klebl FH, L. Tonenchi, Lombardi G, M. Folwaczny, M. Osthoff, Quinton JF, R. Gruber, Ruemmele FM, Seibold F, Seibold F, Shanahan F, Shanahan F, T. Mussack, Torok HP, Torok HP   +29 more
core   +5 more sources

Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

Acta Pharmaceutica Sinica B, 2020
Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral ...
Chang Yan, Zhuo Luo, Wen Li, Xue Li, Robert Dallmann, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +7 more
doaj   +1 more source

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Glas, J., Lohse, P., Török, H. P.   +3 more
core   +1 more source

Cognitive Reserve as a Protective Factor of Mental Health in Middle-Aged Adults Affected by Chronic Pain

Frontiers in Psychology, 2021
Chronic pain is associated with worse mental health and cognitive impairment, which can be a cause or a consequence of brain structure and function alterations, e.g., maladaptive plasticity, antinociceptive system dysregulation.
Selma Delgado-Gallén, Selma Delgado-Gallén, Selma Delgado-Gallén, M. Dolors Soler, M. Dolors Soler, M. Dolors Soler, Sergiu Albu, Sergiu Albu, Sergiu Albu, Catherine Pachón-García, Catherine Pachón-García, Catherine Pachón-García, Vanessa Alviárez-Schulze, Vanessa Alviárez-Schulze, Vanessa Alviárez-Schulze, Javier Solana-Sánchez, Javier Solana-Sánchez, Javier Solana-Sánchez, David Bartrés-Faz, David Bartrés-Faz, David Bartrés-Faz, Josep M. Tormos, Josep M. Tormos, Josep M. Tormos, Alvaro Pascual-Leone, Alvaro Pascual-Leone, Alvaro Pascual-Leone, Gabriele Cattaneo, Gabriele Cattaneo   +28 more
doaj   +1 more source

Genetic Predisposition to SARS-CoV-2 Infection: Cytokine Polymorphism and Disease Transmission within Households

Biology, 2023
We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focused on
Marius Saal, Henry Loeffler-Wirth, Thomas Gruenewald, Ilias Doxiadis, Claudia Lehmann   +4 more
doaj   +1 more source

Shared 6mer Peptides of Human and Omicron (21K and 21L) at SARS-CoV-2 Mutation Sites

Antibodies, 2022
We investigated the short sequences involving Omicron 21K and Omicron 21L variants to reveal any possible molecular mimicry-associated autoimmunity risks and changes in those.
Yekbun Adiguzel, Yehuda Shoenfeld
doaj   +1 more source

Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro

Frontiers in Pharmacology, 2019
Stress has been proven to modulate an individual’s immune system through the release of pituitary and adrenal hormones such as the catecholamines, growth hormone, and glucocorticoids.
Zhuo Luo, Zhuo Luo, Li-Fang Liu, Li-Fang Liu, Xiao-Hua Wang, Xiao-Hua Wang, Wen Li, Wen Li, Chong Jie, Chong Jie, Huan Chen, Huan Chen, Fan-Qin Wei, Dan-Hua Lu, Dan-Hua Lu, Chang-Yu Yan, Chang-Yu Yan, Bo Liu, Hiroshi Kurihara, Hiroshi Kurihara, Yi-Fang Li, Yi-Fang Li, Rong-Rong He, Rong-Rong He   +23 more
doaj   +1 more source

Penicillin Use in Meningococcal Disease Management: Active Bacterial Core Surveillance Sites, 2009. [PDF]

, 2016
In 2009, in the Active Bacterial Core surveillance sites, penicillin was not commonly used to treat meningococcal disease. This is likely because of inconsistent availability of antimicrobial susceptibility testing and ease of use of third-generation ...
Anderson, Raydel, Blain, Amy, Clark, Thomas, Cohn, Amanda, Farley, Monica, Harcourt, Brian, Harrison, Lee, Lynfield, Ruth, MacNeil, Jessica, Mandal, Sema, Mayer, Leonard, Miller, Lisa, Nichols, Megin, Petit, Sue, REINGOLD, Arthur L., Schaffner, William, Thomas, Ann, Wu, Henry, Zansky, Shelley   +18 more
core   +2 more sources

Our unique microbial identity. [PDF]

, 2015
A recent article examines the extent of individual variation in microbial identities and how this might determine disease susceptibility, therapeutic responses and recovery from clinical ...
Gilbert, Jack A
core   +3 more sources