Results 51 to 60 of about 828,302 (264)

The Innate Immune Response of Atlantic Salmon (Salmo salar) Is Not Negatively Affected by High Temperature and Moderate Hypoxia

Frontiers in Immunology, 2020
Climate change is predicted to increase water temperatures and decrease oxygen levels in freshwater and marine environments, however, there is conflicting information regarding the extent to which these conditions may impact the immune defenses of fish ...
Fábio S. Zanuzzo, Anne Beemelmanns, Jennifer R. Hall, Matthew L. Rise, Anthony K. Gamperl   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Cultivar and Training System Impact Cold-climate Seedless Table Grape Performance in the Northeastern United States

HortScience
We grew eight cultivars of seedless table grape in Durham, NH, USA, from 2015 to 2021, using two training systems: Munson and vertical shoot positioning (VSP).
Rebecca Grube Sideman, George Hamilton, Kaitlyn Orde   +2 more
doaj   +1 more source

Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility

Molecular Systems Biology, 2016
The signaling events that drive familial breast cancer (FBC) risk remain poorly understood. While the majority of genomic studies have focused on genetic risk variants, known risk variants account for at most 30% of FBC cases.
Stephen R Piccolo, Laura M Hoffman, Thomas Conner, Gajendra Shrestha, Adam L Cohen, Jeffrey R Marks, Leigh A Neumayer, Cori A Agarwal, Mary C Beckerle, Irene L Andrulis, Avrum E Spira, Philip J Moos, Saundra S Buys, William Evan Johnson, Andrea H Bild   +14 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Restless nights when sick: ectoparasite infections alter rest–activity cycles of diurnal fish hosts

Parasitology
Circadian rhythms are timekeeping mechanisms responsible for an array of biological processes. Disruption of such cycles can detrimentally affect animal health.
Elissavet A. Arapi, Michael Reynolds, Amy R. Ellison, Jo Cable   +3 more
doaj   +1 more source

Gene–Environment Interaction in the Era of Precision Medicine – Filling the Potholes Rather Than Starting to Build a New Road

Frontiers in Genetics, 2020
Gene–environment interaction is a key part of evolutionary biology, animal, and plant breeding, and a number of health sciences, like epidemiology and precision medicine.
José M. Álvarez-Castro
doaj   +1 more source

Disease susceptibility genes for autism

Annals of Medicine, 2003
Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic autism is estimated at over 90 ...
Irina N, Bespalova, Joseph D, Buxbaum
openaire   +2 more sources