Results 61 to 70 of about 875,037 (313)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

YIELDS OF EARL Y RIPENING TOMATO VARIETIES AND IMPACT OF AIR TEMPERATURE DURING MAIN PHASES OF ONTOGENESIS ON FRUIT YIELD

Овощи России, 2016
In accordance with the program of study of selection and crops complex evaluation, the 18 determinant tomato varieties and hybrids of domestic and foreign breeding were used.
P. M. Akhmedova, Y. A. Guseynov, M. A. Umahanov, K. M. Ibragimov   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Differential plague susceptibility in species and populations of prairie dogs

Ecology and Evolution, 2019
Laboratory trials conducted over the past decade at U.S. Geological Survey National Wildlife Health Center indicate that wild populations of prairie dogs (Cynomys spp.) display different degrees of susceptibility to experimental challenge with fully ...
Robin E. Russell, Daniel W. Tripp, Tonie E. Rocke   +2 more
doaj   +1 more source

CISH and Susceptibility to Infectious Diseases [PDF]

New England Journal of Medicine, 2010
The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling.Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major ...
Khor, C.C., Vannberg, F.O., Chapman, S.J., Guo, H., Wong, S.H., Walley, A.J., Vukcevic, D., Rautanen, A., Mills, T.C., Chang, K.-C., Kam, K.-M., Crampin, A.C., Ngwira, B., Leung, C.-C., Tam, C.-M., Chan, C.-Y., Sung, J.J.Y., Yew, W.-W., Toh, K.-Y., Tay, S.K.H., Kwiatkowski, D., Lienhardt, C., Hien, T.-T., Day, N.P., Peshu, N., Marsh, K., Maitland, K., Scott, J.A., Williams, T.N., Berkley, J.A., Floyd, S., Tang, N.L.S., Fine, P.E.M., Goh, D.L.M., Hil, A.V.S.   +34 more
openaire   +4 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Contribution of miR-124 rs531564 polymorphism to the occurrence of congenital Zika syndrome

Epigenetics, 2023
Zika virus (ZIKV) cause Congenital Zika Syndrome (CZS) in individuals exposed during pregnancy. Studies have shown that ZIKV infection positively regulates the miR-124 expression in neural cells, which leads to a decrease of TFRC, a gene targeted of this
Julia A Gomes, Igor Araujo Vieira, Eduarda Sgarioni, Ana Cláudia P Terças-Tretell, Juliana H da Silva, Bethânia FR Ribeiro, Marcial F Galera, Thalita M de Oliveira, Maria Denise F Carvalho de Andrade, Isabella F Carvalho, Lavínia Schüler-Faccini, Fernanda SL Vianna   +11 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cultivar and Training System Impact Cold-climate Seedless Table Grape Performance in the Northeastern United States

HortScience
We grew eight cultivars of seedless table grape in Durham, NH, USA, from 2015 to 2021, using two training systems: Munson and vertical shoot positioning (VSP).
Rebecca Grube Sideman, George Hamilton, Kaitlyn Orde   +2 more
doaj   +1 more source