Results 51 to 60 of about 875,037 (313)
Understanding Disease Susceptibility through Population Genomics [PDF]
Genomics & Informatics, 2012 Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are ...
Seonggyun Han, Junnam Lee, Sangsoo Kim
doaj +1 more source
Genetic susceptibility in Parkinson's disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009 It is hoped that an understanding of the genetic basis of Parkinson's disease (PD) will lead to an appreciation of the molecular pathogenesis of disease, which in turn will highlight potential points of therapeutic intervention. It is also hoped that such an understanding will allow identification of individuals at risk for disease prior to the onset ...
Bras, Jose Miguel, Singleton, Andrew
openaire +2 more sources
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever
Asian Pacific Journal of Tropical Medicine, 2019 Objective: To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya Fever. Methods: A total of 177 individuals were studied: 73 patients with a confirmed diagnosis for Chikungunya ...
Daniela M Rauseo +1 more
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Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin +11 more
wiley +1 more source
iScienceSummary: Prenatal stress has been extensively documented as a contributing factor to adverse cardiac development and function in fetuses and infants. The release of glucocorticoids (GCs), identified as a significant stressor, may be a potential factor ...
Chang-Yu Yan +15 more
doaj +1 more source
Journal of Agriculture and Food ResearchAspartame (ASP), a widely used artificial sweetener, has been reported to exert potential neurotoxic, hepatotoxic, nephrotoxic, and genotoxic effects; however, its impact on bone formation and skeletal homeostasis remains poorly understood. In this study,
Chang-Yu Yan +9 more
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Pollutants and Their Interaction with Diseases of Social Hymenoptera
Insects, 2020 Many insect species, including social insects, are currently declining in abundance and diversity. Pollutants such as pesticides, heavy metals, or airborne fine particulate matter from agricultural and industrial sources are among the factors driving ...
Heike Feldhaar, Oliver Otti
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Medulloblastoma, macrocephaly, and a pathogenic germline PTEN variant: Cause or coincidence?
Molecular Genetics & Genomic Medicine, 2020 Background Medulloblastomas (MBs) are a heterogeneous group of childhood brain tumors with four consensus subgroups, namely MBSHH, MBWNT, MBGroup 3, and MBGroup 4, representing the second most common type of pediatric brain cancer after high‐grade ...
Jussi‐Pekka Tolonen +6 more
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