Results 51 to 60 of about 6,182,453 (264)

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo. [PDF]

, 2010
BACKGROUND: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.
Bennett, DC, Jin, Y., Weetman, A.P., van Geel, Nanja, Gawkrodger, DJ, Hutton, SM, Jouary, T, Bennett, D.C., Sufit, AJ, Kemp, E.H., Gowan, K, Picardo, M, Mailloux, CM, Fain, PR, Hutton, S.M., Weetman, AP, Taïeb, A., Spritz, RA, Lambert, J., Kemp, EH, Leone, G., Spritz, R.A., Overbeck, A., Amadi-Myers, A, van Geel, NanjaGE34UZGent0019989522538010015029510000-0002-3249-8195FB35B7E6-F0ED-11E1-A9DE-61C894A0A6B4, Birlea, S.A., Amadi-Myers, A., Wallace, MR, Wallace, M.R., Riccardi, SL, Birlea, SA, Leone, G, Jouary, T., Jin, Y, van Geel, N, Gowan, K., van Geel, N., Mailloux, C.M., Overbeck, A, McCormack, W.T., Picardo, M., Riccardi, S.L., Fain, P.R., Ezzedine, K., Lambert, J, Ezzedine, K, Sufit, A.J., Lambert, JoGE34UZGent8010010521050000-0001-5303-9310F4F50E9A-F0ED-11E1-A9DE-61C894A0A6B4, Holland, PJ, McCormack, WT, Sufit, AJD, Lambert, Jo, Holland, P.J., Gawkrodger, D.J., Taïeb, A   +54 more
core   +1 more source

Antioxidant dipeptide, cyclo (Phe-Phe), protects against bone dysplasia by suppression of phospholipid peroxidation

Cell Investigation
Prenatal exposure to dexamethasone (Dex) has been identified as a significant factor that impairs longitudinal skeletal growth in fetuses, resulting in notable deficiencies in bone development.
Qiong-Yi Zhang, Rong-Ping Huang, Fang Wu, Hui-Er Ye, Chang-Yu Yan, Hai-Biao Gong, Cai-Ling Xu, Xi-You Li, Shao-Cong Han, Xiao-Min Li, Lei Liang, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +13 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Circadian gene variants and susceptibility to type 2 diabetes : a pilot study [PDF]

, 2012
Background Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility.
O’Hare J. Paul, Shahrad Taheri (57360), M. Ann Kelly (174447), Shera, A. Samad, Hydrie MZ, Barnett, Anthony H., Taheri, S., Anthony H Barnett, Kumar S, Shera, A.S., Rees, Simon D., Kelly, M. Ann, Kelly, Marilyn, Shera, AS, Raychaudhuri, Soumya, Sudhesh Kumar (89490), Abdul Basit (174463), Bellary, Srikanth, Rees, S.D., Kumar, S., Barnett AH, J Paul O'Hare, M. Zafar I. Hydrie (174450), Basit, A., Bellary Srikanth, O'Hare, JP, Bellary S, Shera, A Samad, Taheri S, DIAGRAM Consortium, Hydrie, MZ, Taheri, Shahrad, M Zafar I Hydrie, Bellary, S., Abdul Basit, Hydrie M. Zafar I., Shera A. Samad, Barnett, Anthony, Bellary, S, Basit Abdul, Basit, A, Rees SD, Kumar Sudhesh, Srikanth Bellary (89487), Rees, Simon D, Sudhesh Kumar, Shahrad Taheri, O'Hare, J Paul, Rees, Simon, Kelly, M Ann, SAT2D Consortium, Hydrie, M.Z.I., Kelly MA, A Samad Shera, Basit, Abdul, Barnett, A.H., Anthony H. Barnett (174467), Rees Simon D., Kelly, M.A., Srikanth Bellary, Shera AS, Basit A, Hydrie, M Zafar I, Hydriem, Zafar L., Kumar, Sudhesh, Barnett, Anthony H, O'Hare, J.P., Kelly M. Ann, Hydrie, M. Zafar I., Simon D Rees, Kumar, S, A. Samad Shera (174452), O'Hare, J. Paul, Taheri Shahrad, Barnett Anthony H., J. Paul O’Hare (174457), M Ann Kelly, Simon D. Rees (174448)   +77 more
core   +1 more source

Understanding Disease Susceptibility through Population Genomics [PDF]

Genomics & Informatics, 2012
Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are ...
Seonggyun Han, Junnam Lee, Sangsoo Kim
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Török, H. P., Lohse, P., Glas, J.   +3 more
core   +1 more source

X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya Fever. Methods: A total of 177 individuals were studied: 73 patients with a confirmed diagnosis for Chikungunya ...
Daniela M Rauseo, Mercedes Fernández-Mestre   +1 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2

iScience
Summary: Prenatal stress has been extensively documented as a contributing factor to adverse cardiac development and function in fetuses and infants. The release of glucocorticoids (GCs), identified as a significant stressor, may be a potential factor ...
Chang-Yu Yan, Yue Ye, Han-Lu Mu, Tong Wu, Wen-Shan Huang, Yan-Ping Wu, Wan-Yang Sun, Lei Liang, Wen-Jun Duan, Shu-Hua Ouyang, Rui-Ting Huang, Rong Wang, Xin-Xin Sun, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +15 more
doaj   +1 more source