Results 161 to 170 of about 51,218 (319)

EC3, a Novel Heterodimeric Disintegrin from Echis carinatus Venom, Inhibits α4 and α5 Integrins in an RGD-independent Manner [PDF]

, 1999
Cezary Marcinkiewicz, Juan J. Calvete, Mariola M. Marcinkiewicz, Manfred Raida, Senadhi Vijay‐Kumar, Ziwei Huang, Roy R. Lobb, Stefan Niewiarowski   +7 more
openalex   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Cerebral microbleeds result in increased brain iron and lipid peroxidation in DSAD, consistent with ferroptosis as reported for Alzheimer's disease. Aβ; beta‐amyloid peptides, APP; amyloid precursor protein, GCLC; glutathione cysteine ligase catalytic subunit, GCLM; glutathione cysteine modifier subunit, GPx4; glutathione peroxidase 4, HNE; 4 ...
Max A. Thorwald, Jose A. Godoy‐Lugo, Elizabeth Kerstiens, Gilberto Garcia, Minhoo Kim, Sarah J. Shemtov, Justine Silva, Salma Durra, Peggy A. O'Day, Wendy J. Mack, Annie Hiniker, Marc Vermulst, Bérénice A. Benayoun, Ryo Higuchi‐Sanabria, Henry Jay Forman, Elizabeth Head, Caleb E. Finch   +16 more
wiley   +1 more source

Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7

Glia, Volume 73, Issue 6, Page 1288-1306, June 2025.
Main Points MMP7 is not essential for demyelination and remyelination in the cuprizone model. MMP7‐/‐ mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7‐/‐ mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter, Andrea J. Arreguin, Wendy Oost, Jenny C. de Jonge, Harm H. Kampinga, Sandra Amor, Holly Colognato, Wia Baron   +7 more
wiley   +1 more source

ADAM 12, a Disintegrin Metalloprotease, Interacts with Insulin-like Growth Factor-binding Protein-3 [PDF]

, 2000
Zengdun Shi, Wenzhong Xu, Frosty Loechel, Ulla M. Wewer, Liam J. Murphy   +4 more
openalex   +1 more source

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function [PDF]

, 2000
Takayuki Shindo, Hiroki Kurihara, Kouji Kuno, Hitoshi Yokoyama, Takashi Wada, Yukiko Kurihara, T. Imai, Yuhui Wang, Masafumi Ogata, Hiroaki Nishimatsu, Nobuo Moriyama, Yoshio Oh-hashi, Hiroyuki Morita, Takatoshi Ishikawa, Ryozo Nagai, Yoshio Yazaki, Kouji Matsushima   +16 more
openalex   +1 more source

Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

Cellular and Molecular Life Sciences, 2019
Hung-En Hsia, Johanna Tüshaus, Tobias Brummer, Yuanpeng Zheng, Simone D Scilabra, S. Lichtenthaler   +5 more
semanticscholar   +1 more source

Genetic and Inflammatory Signatures Associated With Worse Prognosis in Hospitalized Patients With Severe SARS‐CoV‐2 Infection With and Without Diabetes

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SAR‐CoV‐2) presents with a diverse symptomology, ranging from asymptomatic to severe disease, but the mechanism of risk factors such as diabetes remains unelucidated. The current retrospective cohort study of 182 patients, with and without COVID‐19 and diabetes, analyzed leftover blood specimens
Marshall Yuan, Andrew Wassef, Davit Sargsyan, Vahe Nersisyan, Javier Cabrera, Ronald G. Nahass, Wael Hassan, Ah‐Ng Kong, Luigi Brunetti   +8 more
wiley   +1 more source

The importance of early immunotherapy in patients with faciobrachial dystonic seizures. [PDF]

, 2018
Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with faciobrachial dystonic seizures and LGI1 antibodies to understand ...
Bi, Mian, Bien, Christian, Chu, Kon, Farooque, Pue, Gelfand, Jeffrey, Geschwind, Michael, Hirsch, Lawrence, Irani, Sarosh, Lang, Bethan, Leite, Maria, Makuch, Mateusz, Murchison, Andrew, Somerville, Ernest, Thompson, Julia, Vincent, Angela, Waters, Patrick   +15 more
core  

Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin α5β1 antagonist from Eristocophis macmahoni venom [PDF]

, 2000
Juan J. Calvete, Michael Jürgens, Cezary Marcinkiewicz, Antonio Romero, Michael Schrader, Stefan Niewiarowski   +5 more
openalex   +1 more source