Results 141 to 150 of about 77,378 (253)

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source

The Metalloprotease Disintegrin ADAM8 [PDF]

Journal of Biological Chemistry, 2002
Uwe Schlomann, Dirk Wildeboer, Ailsa Webster, Olga Antropova, Dagmar Zeuschner, C. Graham Knight, Andrew J.P. Docherty, Marc Lambert, Lisa Skelton, Harald Jockusch, Jörg W. Bartsch   +10 more
openaire   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable, Yasamin Minazadeh, Lane B. Buchanan, Henryroger Ssemunywa, Ronald M. Galiwango, Rupert Kaul, Jessica L. Prodger   +6 more
wiley   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice [PDF]

, 2017
A Bruni-Cardoso, A Carriero, A Carriero, A Carriero, A Janssen, A Ural, Adele Boskey, AL Boskey, AL Boskey, Alessandra Carriero, Andrew A. Pitsillides, B Javaheri, Behzad Javaheri, BH Weber, Brendyn Miller, CH Turner, D Stickens, E Donnelly, E Ohuchi, EL Martin, EP Paschalis, FF Mohammed, George Bou-Gharios, H Isaksson, H Zhao, HH Malluche, J Verstappen, K Bell, K Brew, K Holmbeck, K Verdelis, KJ Leco, L Hammoud, L Spevak, Lyudmila Lukashova, Lyudmila Spevak, M Federici, M Inada, M Marzia, ME Marisa, ML Bouxsein, P Garnero, PW Fedak, R Ritchie, R Shigdel, S Sahebjam, S Verrier, SE Gill, SS Apte, T Maretzky, W Cruz-Munoz, Y Shen   +51 more
core   +3 more sources

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Dried plasma retains hemostatic function and thermal stability during Arctic military operations

Transfusion, Volume 66, Issue S1, Page S159-S171, May 2026.
Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh, Aron A. Shoara, Henry T. Peng, Viktor Prifti, Katy Moes, Cerys McGuinness, Tristan Bonnici, Maria Shiu, Sushmaa Chandralekha Selvakumar, Peter Andrisani, Pierre‐Marc Dion, Damien Miller, Sebastian Vuong, Colin A. Kretz, Philip J. Wallace, Shawn G. Rhind, Wendy Sullivan‐Kwantes, Andrew N. Beckett   +17 more
wiley   +1 more source