Results 121 to 130 of about 65,779 (239)

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7‐driven ENO1 deubiquitination during intervertebral disc degeneration

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Under conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Xiaoming Liu, Wenyu Zhang, Hang Feng, Linying Lai, Chen Cao, Guang Yang, Yanzheng Gao, Bijun Wang, Hui Wang, Bin Yu, Zhenghong Yu   +10 more
wiley   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

Cytosolic SH3-interactions of ADAM12-disintegrin-metalloprotease

, 2007
Background: ADAM proteins (a disintegrin and metalloprotease) are membrane proteins that consist of several functional domains. ADAM proteins are able to mediate cell adhesion through their disintegrin domain and selective protein cleavage (e.g ...
TEITTINEN, KAISA
core  

The Glycoprotein B Disintegrin-Like Domain Binds Beta 1 Integrin To Mediate Cytomegalovirus Entry

, 2010
Cellular integrins were identified as human cytomegalovirus (HCMV) entry receptors and signaling mediators in both fibroblasts and endothelial cells. The goal of these studies was to determine the mechanism by which HCMV binds to cellular integrins to ...
Adam L. Feire, Teresa Compton, René M. Roy, Kate Manley   +3 more
core   +1 more source

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source

Aberrant Expression of Disintegrin-Metalloprotease Proteins in the Formation and Progression of Uterine Cervical Cancer

, 2011
<i>Objective:</i> Dysregulated expression of disintegrin-metalloprotease proteins [a disintegrin and metalloproteases (ADAMs) and ADAMs with thrombospondin motif (ADAMTSs)] has been reported in many types of cancers and is believed to play an
Seiji Mori, Masahiko Tsujimoto, Nariaki Matsuura, Naomasa Kawaguchi, Tohru Kiyono, Toru Nakano, Mohammed Shaker, Yuhki Yokoyama   +7 more
core   +1 more source

The Cancer Immunotherapy Thromboembolism Assessment: A Novel Score for Predicting Thromboembolic Events in Melanoma Patients Treated With Immune Checkpoint Inhibition

International Journal of Cancer, Volume 159, Issue 5, Page 1337-1344, 1 September 2026.
Although immune checkpoint inhibitors (ICI) have transformed metastatic melanoma treatment, thromboembolic events (TEEs) remain a serious complication. Moreover, existing risk assessment models were developed prior to ICI use and lack clinical validation.
Tim Zell, Julian Kött, Noah Zimmermann, Greta Ancker, Alexander T. Bauer, Daniel J. Smit, Glenn Geidel, Julian C. Gerwers, Thomas Renné, Sebastian A. Wohlfeil, Jochen Utikal, Stefan W. Schneider, Christoffer Gebhardt   +12 more
wiley   +1 more source

FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION

, 2023
KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric ...
Walker, Lia R., NC DOCKS at East Carolina University   +1 more
core  

Cloning of Metalloprotease Genes in the Carpet Viper (Echis pyramidurm leakeyi): Further Members of the Metalloprotease/Disintegrin Gene Family: Further Members of the Metalloprotease/Disintegrin Gene Family

, 1994
The genes coding for two metalloproteases, EcH‐I and EcH‐II, have been cloned from an Echis pyramidum leakeyi venom gland cDNA library. The cDNA sequences predict two zymogen molecules with strong amino acid sequence similarity and the same domain ...
Crampton, Julian M., Moura‐Da‐Silva, Ana M., Paine, Mark; id_orcid, Theakston, R. David G.   +3 more
core   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source