Results 121 to 130 of about 62,920 (233)

Inhibition of adipogenesis by RGD-dependent disintegrin [PDF]

, 2006
Adipogenesis plays a central role in obesity development. The processes of adipogenesis include migration, adhesion, proliferation & survival of preadipocytes & differentiation to mature adipocytes.
Lin, Yu-Ting; Tang, Chih-Hsin; Chuang, Woei-Jer; Wang, Seu-Mei; Huang, Tur-Fu; Fu, Wen-Mei
core  

Recombinant disintegrin targets alpha(v) beta(3) integrin and leads to mediator production [PDF]

, 2014
Integrin alpha v beta 3 is most likely the foremost modulator of angiogenesis among all known integrins. Recombinant disintegrin DisBa-01, originally obtained from snake venom glands, binds to alpha v beta 3, thereby significantly inhibiting adhesion and
Urbaczek, Ana C. [UNESP], Urbaczek, Ana C., Carlos, Iracilda Zeppone, Selistre-de-Araujo, Heloisa S., Ribeiro, Livia C. A., Tansini, Aline [UNESP], Durante, Araceli C., Massimino, Livia C., Ribeiro, Livia C. A. [UNESP], Tansini, Aline, Massimino, Livia C. [UNESP], Carlos, Iracilda Zeppone [UNESP]   +11 more
core   +1 more source

Structures and Functions of Snake Venom Metalloproteinases (SVMP) from Protobothrops venom Collected in Japan

Molecules, 2017
Snake venom metalloproteinases (SVMP) are widely distributed among the venoms of Crotalinae and Viperidae, and are organized into three classes (P-I, P-II and P-III) according to their size and domain structure.
Etsuko Oyama, Hidenobu Takahashi
doaj   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Tumor cytotoxicity of leucurolysin-B, a P-III snake venom metalloproteinase from Bothrops leucurus

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Although it has been demonstrated that venoms and toxins from some snakes are able to influence the growth of tumor cells, few antitumoral compounds from Bothrops leucurus venom have been characterized.
LM Gabriel, EF Sanchez, SG Silva, RG Santos   +3 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura [PDF]

, 2006
BACKGROUND: The cysteine-rich/spacer domains of ADAMTS13 contain a major binding site for antibodies in patients with acquired thrombotic thrombocytopenic purpura (TTP). OBJECTIVE: To study the heterogeneity of the antibody response towards these domains
van Mourik, J A, Luken, B M, Fijnheer, R, Kaijen, P. H. P., Kremer Hovinga, J A, Luken, B. M., Voorberg, J, Fijnheer, R., Voorberg, J., Kremer Hovinga, J. A., van Mourik, J. A., Turenhout, E A M, Kaijen, P H P, Turenhout, E. A. M.   +13 more
core   +1 more source

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Toxins, 2016
Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues.
Erika Camacho, Libia Sanz, Teresa Escalante, Alicia Pérez, Fabián Villalta, Bruno Lomonte, Ana Gisele C. Neves-Ferreira, Andrés Feoli, Juan J. Calvete, José María Gutiérrez, Alexandra Rucavado   +10 more
doaj   +1 more source

Molecular Cloning And Sequencing Of Disintegrin Like Domain From Cerastes Cerastes Venom Gland [PDF]

, 2008
Disintegrin-like domain was cloned and sequenced from Cerastes cerastes venom gland tissue. Nested RT-PCR was performed using initial primers designed based on the homology of disintegrins from Trimeresurus flavoviridis, Glodius halys , Agkistrodon halys
O Shaker, T Abdel-Aziz, El-Daba, E, M F El-Asmer, A Basheer, D El-Miligy, Basheer, A, El-Miligy, D, E El-Daba, El-Asmer, M F, Abdel-Aziz, T, Shaker, O   +11 more
core   +1 more source

Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association

Clinical Case Reports, 2019
Antiphospholipid syndrome (APS) is an autoimmune disease that demonstrates antiphospholipid antibodies that cause hypercoagulability and leads to venous and arterial thrombosis. Autoantibodies to a disintegrin‐like and metalloprotease with thrombospondin
Hallie Hanna Dolin, Mark Dziuba, Scott M. Pappada, Thomas John Papadimos   +3 more
doaj   +1 more source