Results 131 to 140 of about 65,779 (239)

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin‐based antivenom treatment on murine plasma proteome and peptidome

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros, Alison F. A. Chaves, Mariana S. L. C. Morone, Ana T. A. Sachetto, Marcelo L. Santoro, Oliver Schilling, Solange M. T. Serrano   +6 more
wiley   +1 more source

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8157-8171, September 2026.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

Assessing the Clinical Relevance of Blood Soluble Triggering Receptor Expressed on Myeloid Cells 2 in Neurological Diseases

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Blood sTREM2 is emerging as a potential biomarker of neuroinflammation, yet its biological significance remains poorly understood. In this study, plasma sTREM2 was quantified in 547 individuals across Alzheimer's disease, mild cognitive impairment, multiple sclerosis, ATTR polyneuropathy, asymptomatic ATTR mutation carriers, and healthy controls ...
Luisa Agnello, Caterina Maria Gambino, Giuseppe Salemi, Vincenzo Di Stefano, Tommaso Piccoli, Anna Masucci, Sabrina Novara, Anna Maria Ciaccio, Fabio Del Ben, Daniela Capello, Marcello Ciaccio   +10 more
wiley   +1 more source

Artemotil Attenuates Fibrosis‐Associated Chondrocyte Remodelling in Osteoarthritis in Association With STC1‐Related TGF‐β/SMAD2/3 Signalling

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Cartilage fibrosis contributes to extracellular matrix remodelling and structural deterioration during osteoarthritis (OA) progression; however, the molecular regulators involved in this process remain incompletely understood. Stanniocalcin‐1 (STC1) has been implicated in tissue remodelling and fibrosis‐associated signalling, but its role in ...
Guang Zhu, Yang Yang, Ye Ma, Gang Wu, Kuanmin Tian, Xiaoxin He, Rui Wang, Penggang Ma, Zhiqun Tang, Qunhua Jin   +9 more
wiley   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Disintegrin Domain [PDF]

, 2020
openaire   +1 more source

Inhibition of adipogenesis by RGD-dependent disintegrin

, 2006
Adipogenesis plays a central role in obesity development. The processes of adipogenesis include migration, adhesion, proliferation & survival of preadipocytes & differentiation to mature adipocytes.
Lin, Yu-Ting; Tang, Chih-Hsin; Chuang, Woei-Jer; Wang, Seu-Mei; Huang, Tur-Fu; Fu, Wen-Mei
core  

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer <i>in vitro</i> and <i>in vivo</i>. [PDF]

Mol Med Rep
Chang L, Gong F, Cui Y.
europepmc   +1 more source