Results 91 to 100 of about 2,381,058 (285)
A tale of two crises: COVID-19 and climate
Sustainability: Science, Practice, & Policy, 2020 In response to the COVID-19 pandemic, governments around the world are mobilizing unprecedented public resources to mitigate economic collapse. However, these new programs run the risk of paying insufficient attention to the multiple sustainability ...
Jochen Markard, Daniel Rosenbloom
doaj +1 more source
Balancing operating revenues and occupied refurbishment costs 1: problems of defining project success factors and selecting site planning methods [PDF]
, 2007 In planning the refurbishment of railway stations the spatial needs of the contractor and of the ongoing business stakeholders have to be balanced. A particular concern is the disruptive effect of construction works upon pedestrian movement.
Kelsey, J
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Transportation, Terrorism and Crime: Deterrence, Disruption and Resilience [PDF]
, 2020 : Terrorists likely have adopted vehicle ramming as a tactic because it can be carried out by an individual (or “lone wolf terrorist”), and because the skills required are minimal (e.g.
Edwards, Frances L., Goodrich, Daniel C.
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Business Strategy Review, 2014 Can online P2P lenders deliver disruptive innovation to the world of banking?
Jeffery, P, Arnold, D
openaire +1 more source
, 2015 The disruption of stars by supermassive black holes has been linked to more than a dozen flares in the cores of galaxies out to redshift $z \sim 0.4$. Modeling these flares properly requires a prediction of the rate of mass return to the black hole after
Antonini +43 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
CellsBackground: Preeclampsia (PE) is a critical complication of pregnancy that affects 3% to 5% of all pregnancies and has been linked to aberrant placentation, causing severe maternal and fetal illness and death.
Balu Usha Rani +4 more
doaj +1 more source