Results 51 to 60 of about 1,178,957 (338)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release Testing

AAPS Journal, 2019
This manuscript represents the perspective of the Dissolution Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) and of two focus groups of the American Association of Pharmaceutical Scientists ...
N. Zaborenko, Zhenqi Shi, Claudia C. Corredor, Brandye Smith-Goettler, Limin Zhang, Andre Hermans, C. Neu, Md Anik Alam, Michael J. Cohen, Xujin Lu, Leah Xiong, Brian M. Zacour   +11 more
semanticscholar   +1 more source

Sticky physics of joy: On the dissolution of spherical candies

, 2012
Assuming a constant mass-decrease per unit-surface and -time we provide a very simplistic model for the dissolution process of spherical candies. The aim is to investigate the quantitative behavior of the dissolution process throughout the act of eating ...
Andreas Windisch, Anita Windisch, Herbert Windisch, Rhoades R A   +3 more
core   +1 more source

Study of the microstructure resulting from brazed aluminium materials used in heat exchangers [PDF]

, 2005
Re-solidification of AA4343 cladding after brazing as well as the related precipitation in the modified AA3003 core material have been investigated. Analysis of the re-solidified material showed that partial dissolution of the core alloy occurs in both ...
Alexandre, Balitchev, Barlock, Benedictus, C. Blanc, D. Daloz, D. Vaumousse, Davignon, Flemings, G. Mankowski, H. Robidou, J. Lacaze, Kral, Krendelsberger, Li, M.-C. Lafont, Marshall, Munson, N. Pébère, S. Tierce, Sundman, Tierce, Y. Thebault, Zakharov   +23 more
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Effect of Soil Organic Matter, Soil pH, and Moisture Content on Solubility and Dissolution Rate of CuO NPs in Soil.

Environmental Science and Technology, 2019
The objectives of this research were to quantify the impact of organic matter content, soil pH and moisture content on the dissolution rate and solubility of copper oxide nanoparticles (CuO NPs) in soil, and to develop an empirical model to predict the ...
Xiaoyu Gao, S. Rodrigues, Eleanor Spielman-Sun, Sónia P. Lopes, Sandra Rodrigues, Yilin Zhang, A. Avellan, R. M. Duarte, A. Duarte, Elizabeth A. Casman, G. Lowry   +10 more
semanticscholar   +1 more source

Gallstone Dissolution

Surgical Clinics of North America, 1990
Many methods are available for gallstone dissolution, including oral bile salts; cholesterol solvents such as mono-octanoin or methyl tert-butyl either; and calcium or pigment solvents such as EDTA and polysorbate. Which of these approaches will be appropriate for an individual patient depends on the type of stones; whether they are in the gallbladder ...
M A, Talamini, T R, Gadacz
openaire   +2 more sources

Changes in dissolved iron deposition to the oceans driven by human activity: a 3-D global modelling study [PDF]

, 2015
The global atmospheric iron (Fe) cycle is parameterized in the global 3-D chemical transport model TM4-ECPL to simulate the proton- and the organic ligand-promoted mineral-Fe dissolution as well as the aqueous-phase photochemical reactions between the ...
Baker, Alex, Daskalakis, Nikos, Kanakidou, Maria, Mihalopoulos, Nikos, Myriokefalitakis, Stelios, Nenes, Athanasios   +5 more
core   +2 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Roche volume filling and the dissolution of open star clusters

, 2015
From direct N-body simulations we find that the dynamical evolution of star clusters is strongly influenced by the Roche volume filling factor. We present a parameter study of the dissolution of open star clusters with different Roche volume filling ...
Berczik, P., Ernst, A., Just, A., Noel, T.   +3 more
core   +1 more source