Results 31 to 40 of about 41,703 (248)

In Vitro Dissolution Enhancement of Felodipine

Indo Global Journal of Pharmaceutical Sciences, 2011
Purpose: With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug
V P Patel, M C Gohel, null R K Parikh
openaire   +1 more source

Enhancement of ketoconazole dissolution rate by the liquisolid technique [PDF]

Acta Pharmaceutica, 2018
Abstract The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier, coating substance, nonvolatile solvent and additive ...
Molaei, Mir-Ali, Osouli-Bostanabad, Karim, Adibkia, Khosro, Shokri, Javad, Asnaashari, Solmaz, Javadzadeh, Yousef   +5 more
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Triboelectrification and dissolution property enhancements of solid dispersions [PDF]

International Journal of Pharmaceutics, 2015
The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles. Particle triboelectrification plays an important part in powder processing, affecting end product quality due to particle deposition and powder loss.
Kofi Asare-Addo, Enes Šupuk, Hiba Al-Hamidi, Samuel Owusu-Ware, Ali Nokhodchi, Barbara R. Conway   +5 more
openaire   +2 more sources

Ultrasonically-Assisted Dissolution of Sugarcane Bagasse during Dilute Acid Pretreatment: Experiments and Kinetic Modeling

Energies, 2020
Ultrasonic irradiation is known to enhance various physicochemical processes. In this work, the effect of ultrasound on the dissolution of sugarcane bagasse was studied, with the specific aims of quantifying the effect at low solids loading and mild ...
Deslin Nadar, Kubendren Naicker, David Lokhat   +2 more
doaj   +1 more source

Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges

Pharmaceutics, 2018
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-laden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs.
Anagha Bhakay, Mahbubur Rahman, Rajesh N. Dave, Ecevit Bilgili   +3 more
doaj   +1 more source

Enhanced Dissolution of Oil Shale by Bioleaching with Thiobacilli [PDF]

Applied and Environmental Microbiology, 1976
Oil shale was subjected to bioleaching by cultures of thiobacilli. From X-ray, electron microprobe, and thin-section petrographic analysis, the shale matrix was found to contain tightly bonded carbonate minerals. When subjected to the bioproduced acids, these carbonate minerals were removed successively from the shale matrix.
W C, Meyer, T F, Yen
openaire   +2 more sources

Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets

Pharmaceutics, 2020
Fenofibrate-loaded electrospun microfibrous sheets were prepared in an attempt to enhance the dissolution of the poorly soluble antihyperlipidemic agent and to improve its bioavailability.
Emese Sipos, Tamás Csatári, Adrienn Kazsoki, Attila Gergely, Enikő Bitay, Zoltán-István Szabó, Romána Zelkó   +6 more
doaj   +1 more source

An Approach to Enhance Dissolution Rate of Tamoxifen Citrate

BioMed Research International, 2019
We tested the solubility and dissolution of tamoxifen citrate to ascertain the optimal conditions for faster dissolution. Using the solvent evaporation method and hydrophilic carriers, we formulated tamoxifen citrate (TC) that contained solid dispersions (SDs).
Nagaraja SreeHarsha, Jagadeesh G. Hiremath, Swathi Chilukuri, Rajesh Kumar Aitha, Bandar E. Al-Dhubiab, Katharigatta N. Venugopala, Abdullah Mossa Alzahrani, Girish Meravanige   +7 more
openaire   +2 more sources

DISSOLUTION BEHAVIOUR OF PROPYLTHIOURACIL POLYVINYLPYRROLIDONE SOLID DISPERSIONS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1988
The objective of the present study was to investigate the influence of variation of the molecular weight and the proportion of polyvinylpyrrolidone (PVPs) on the dissolution of propylthiouracil (Pt) as a model of sparingly soluble drugs dispersed in ...
A. Aboutaleb, A. El-Sayed, S. Abdel-Rahman   +2 more
doaj   +1 more source

Visualization of polysulfide dissolution in lithium-sulfur batteries using in-situ NMR microimaging

Electrochemistry Communications, 2022
Lithium-sulfur batteries offer the highest theoretical energy density among enclosed rechargeable batteries. However, there are various issues that need to be addressed before their practical adoption, such as the dissolution of intermediate lithium ...
Arunkumar Dorai, Junichi Kawamura, Takahisa Omata   +2 more
doaj   +1 more source