Results 21 to 30 of about 41,703 (248)

Formulation Development of Mirtazapine Liquisolid Compacts: Optimization Using Central Composite Design

Molecules, 2022
Mirtazapine is a tetracyclic anti-depressant with poor water solubility. The aim of this study was to improve the dissolution rate of mirtazapine by delivering the drug as a liquisolid compact.
Faiza Naureen, Yasar Shah, Sayyed Ibrahim Shah, Muhammad Abbas, Inayat Ur Rehman, Salar Muhammad, Hamdullah Hamdullah, Khang Wen Goh, Fazli Khuda, Amjad Khan, Siok Yee Chan, Mehwish Mushtaq, Long Chiau Ming   +12 more
doaj   +1 more source

DESIGN, FORMULATION AND EVALUATION OF CELECOXIB SOLID DISPERSIONS PREPARED BY THE SOLVENT- EVAPORATION TECHNIQUE [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2013
The aim of the present study was to improve dissolution of poorly water-soluble Celecoxib by solid dispersion technique using water soluble carriers. Solid dispersions of Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl ...
Yasmin Mortagi
doaj   +1 more source

Impact of the manufacturing technique on the dissolution-enhancement functionality of PEG4000 in Cilostazol tablets [PDF]

Pharmacia, 2021
Cilostazol was selected as poorly-soluble model drug to investigate the impact of the manufacturing method on the excipient functionality of PEG4000 at various levels.
Obada Sawafta, Sonia Alhadid, Izz Aldeen Abu Awwad, Eman Migdadi, Ahmad Aljaberi   +4 more
doaj   +3 more sources

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Pharmaceutics, 2020
Despite the wide-spread use of liposomal drug delivery systems, application of these systems for oral purposes is limited due to their large-scale formulation and storage issues.
Maryam Farzan, Gabriela Québatte, Katrin Strittmatter, Florentine Marianne Hilty, Joachim Schoelkopf, Jörg Huwyler, Maxim Puchkov   +6 more
doaj   +1 more source

Lignin enhances cellulose dissolution in cold alkali

Carbohydrate Polymers, 2021
Aqueous sodium hydroxide solutions are extensively used as solvents for lignin in kraft pulping. These are also appealing systems for cellulose dissolution due to their inexpensiveness, ease to recycle and low toxicity. Cellulose dissolution occurs in a narrow concentration region and at low temperatures.
Costa, Carolina, Medronho, Bruno, Eivazi, Alireza, Svanedal, Ida, Lindman, Björn, Edlund, Håkan, Norgren, Magnus   +6 more
openaire   +6 more sources

Preparation and characterization of fenofibrate-loaded zeolitic imidazolate frameworks and their evaluation in dissolution enhancement of the formulation [PDF]

شیمی کاربردی روز, 2021
The purpose of this study was to develop zeolitic imidazolate frameworks (ZIFs) incorporated with poorly water-soluble drug fenofibrate (FEN), belonging to Biopharmaceutical Classification System (BCS) class II, to improve drug dissolution, intended to ...
Aziz maleki, Ziba Islambulchilar, Roya Poornorouz, Mehrdad Hamidi, Masoumeh Kord, Mohammad Ali Shahbazi   +5 more
doaj   +1 more source

ENHANCEMENT OF DISSOLUTION OF CANDESARTAN CILEXETIL

Asian Journal of Pharmaceutical and Clinical Research, 2023
Objective: The main aim of our investigation was to enhance the dissolution of Candesartan Cilexetil (CC), a prodrug of Candesartan, used in the treatment of hypertension. CC bioavailability is dissolution rate limited. The drug was formulated using various excipients such as surfactants, and liquid lipids to improve solubility, dissolution, and hence ...
APARNA C, ANUSHA M, MANISHA B
openaire   +1 more source

Dissolution Enhancement of Artemisinin with .BETA.-Cyclodextrin

Chemical and Pharmaceutical Bulletin, 2011
The main objective of this research is to improve the dissolution rate of artemisinin (ART) by fabrication with β-cyclodextrin (β-CD) as a hydrophilic carrier. Artemisinin nanoparticles and ART/β-CD complexes were successfully fabricated by means of evaporative precipitation of nanosuspension.
Kakran, Mitali, Sahoo, Nanda Gopal, Li, Lin, Judeh, Zaher   +3 more
openaire   +3 more sources

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Dissolution enhancement of chlorzoxazone using cogrinding technique.

Int J Pharm Investig, 2015
The aim of the present work was to improve rate of dissolution and processing parameters of BCS class II drug, chlorzoxazone using cogrinding technique in the presence of different excipients as a carrier.The drug was coground with various carriers like polyethylene glycol (PEG 4000), hydroxypropyl methylcellulose (HPMC) E50LV, polyvinylpyrrolidone ...
Raval MK, Patel JM, Parikh RK, Sheth NR.
europepmc   +4 more sources