Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on mPEG-PCL Amphiphilic Copolymer and Fe-BTC Porous Metal-Organic Framework [PDF]
Nanomaterials, 2020 In the present work, the porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance the solubility of the anticancer drug paclitaxel (PTX) and to prepare controlled release formulations after its
Nikolaos D. Bikiaris +7 more
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Efavirenz Dissolution Enhancement I: Co-Micronization [PDF]
Pharmaceutics, 2012 AIDS constitutes one of the most serious infectious diseases, representing a major public health priority. Efavirenz (EFV), one of the most widely used drugs for this pathology, belongs to the Class II of the Biopharmaceutics Classification System for ...
Helvécio Vinícius Antunes Rocha +5 more
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Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement [PDF]
Pharmaceutics, 2018 In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal +4 more
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Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
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Dissolution enhancement of Gefitinib by solid dispersion and complexation with β-cyclodextrins: In vitro testing, cytotoxic activity, and tablet formulation [PDF]
Saudi Pharmaceutical JournalCancer is the leading cause of mortality worldwide. In patients with metastatic non-small cell lung cancer, epidermal growth factor receptor (EGFR) is often overexpressed.
Adel F. Alghaith +8 more
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Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds
Pharmaceuticals, 2022 The current review is based on the advancements in the field of natural therapeutic agents which could be utilized for a variety of biomedical applications and against various diseases and ailments.
Meshal Alshamrani +4 more
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Comparative evaluation of ternary amorphous solid dispersions: Identifying optimal excipient systems for enhancing drug solubility [PDF]
International Journal of Pharmaceutics: XThe limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability, therapeutic efficacy, and clinical translation.
Arif Budiman +9 more
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Polytechnic Journal, 2021 Drugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability.
Hemn L. Qader +2 more
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Pharmaceutics, 2022 This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using microcrystalline ...
Ekapol Limpongsa +3 more
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PREPARATION AND EVALUATION OF NAPROXEN ADSORBATE AS AN ATTEMPT TO IMPROVE DRUG DISSOLUTION CHARACTERISTICS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2004 Naproxen is a nonsteroidal anti-inflammatory drug which shows variable absorption and bioavailability due to its poor solubility. In this study we aimed to improve the dissolution rate of the drug by solvent deposition onto certain adsorbents including ...
S. Khalaf, K. Saleh, Ahmed Ismail
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