Results 171 to 180 of about 56,903 (208)

Improved dissolution behaviour of steam-granulated piroxicam

European Journal of Pharmaceutics and Biopharmaceutics, 2002
In this paper we prepared and characterized improved release granulates containing Piroxicam and beta-cyclodextrins (1:2.5 molar ratio), obtained by steam-aided granulation, using a one-step rotogranulator, Rotolab. These granulates were compared to those prepared by traditional wet granulation, to the physical mixture, and to the kneaded and dry ...
Cristina, Cavallari, Beatrice, Albertini, Marisa L, González-Rodríguez, Lorenzo, Rodriguez, Beatrice, Abertini   +4 more
openaire   +2 more sources

Improved Holder for Intrinsic Dissolution Rate Studies

Journal of Pharmaceutical Sciences, 1965
An improved holder for use in rotational disk dissolution studies has been developed. The compression die becomes the rotating member. With it, the relative intrinsic dissolution rates at 37° in 0.1 N HC1 with 430 r.p.m. rotational speed have been found to be caffeine monohydrate, 106, aspirin, 9.73, salicylamide, 12.3, and acetaminophen, 41.7 ...
J, Wood, J, Syarto, H, Letterman
openaire   +2 more sources

Improved Dissolution Behavior of Fenbufen by Spherical Crystallization

Drug Development and Industrial Pharmacy, 1999
Fenbufen is an analgesic, antipyretic and anti-inflammatory drug that is characterized by poor water solubility, a defect increased by very low wettability. Poor water solubility, particularly at low pH, could decrease absorption in the upper part of the gastrointestinal tract, which would be inconvenient for good bioavailability.
DI MARTINO, Piera, C. Barthélémy, F. Piva, E. Joiris, PALMIERI, Giovanni Filippo, S. Martelli   +5 more
openaire   +3 more sources

Using biochemical system to improve cinnabar dissolution

Bioresource Technology, 2013
In order to evaluate the leaching of cinnabar, a chemobiological reactor system with Acidithiobacillus ferrooxidans for cinnabar dissolution was investigated. The results demonstrated cinnabar dissolution had relation to bioprocess of A. ferrooxidans and iron concentration tightly. The optimal dilution rate and iron concentration were 0.4/h and 2-3 g/L
Y J, Wang, H Y, Li, H F, Hu, D P, Li, Y J, Yang, C, Liu   +5 more
openaire   +2 more sources

MCM-41 for furosemide dissolution improvement

Microporous and Mesoporous Materials, 2012
Abstract The ordered mesoporous silica material MCM-41 was used to prepare a novel drug delivery system (DDS) for oral administration of the diuretic furosemide (FURO), labeled in class IV of the Biopharmaceutics Classification System (BCS). This drug is characterized by both low solubility and permeability and its absorption window is the stomach ...
AMBROGI, Valeria, PERIOLI, Luana, PAGANO, CINZIA, LATTERINI, Loredana, MARMOTTINI, Fabio, RICCI, Maurizio, ROSSI, Carlo   +6 more
openaire   +2 more sources

Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds

Pharmaceutical Research, 2008
To demonstrate improvement in the dissolution of exemestane and megestrol acetate from cocrystallization using various particle sizes and to investigate the mechanism of the improved dissolution.Cocrystal screening was performed by slurry crystallization.
Koji Shiraki, Noriyuki Takata, Ryusuke Takano   +2 more
exaly   +3 more sources

Improvement in solubility and dissolution rate of flavonoids by complexation with β-cyclodextrin

Journal of Pharmaceutical and Biomedical Analysis, 2004
The inclusion into the beta-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of beta-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different
D Raneri, Maria Luisa Calabro, Rosanna Stancanelli   +2 more
exaly   +3 more sources

An Improved Method for Dissolution of Uranium Tetrafluoride.

Analytical Chemistry, 1962
Dissolution of UF/sub 4 in a mixture of (NH/sub 4/)/sub 2/ SO/sub 4/ and H/s ub 2/SO/sub 4/ and boric acid is described. For large-sized samples, addition of boric acid appreciably hastened dissolution, and a 15-gram sample was dissolved in 30 min in quartz glassware. The cooled melt is soluble in distilled water. (M.C.G.)
W. M. Wise, H. R. Soehnlin, C. H. McBride   +2 more
openaire   +1 more source

Improvement of Dissolution Properties of Furosemide by Complexation with β-Cyclodextrin

Drug Development and Industrial Pharmacy, 1998
The purpose of this study was to increase the solubility of furosemide (FR) with inclusion compound of beta-cyclodextrin (beta-CD). The interaction between FR and beta-CD in solution was studied by the solubility method. The phase solubility studies reveal a Bs-type diagram with an inclusion complex of 1:1 molar ratio and a stability constant of 823.5 ...
N, Ozdemir, S, Ordu
openaire   +2 more sources

Ternary solid dispersion to improve solubility and dissolution of meloxicam

Journal of Basic and Clinical Physiology and Pharmacology, 2019
Abstract Background Meloxicam (MLX) is a potent non-steroidal anti-inflammatory drug with poor solubility. Solid dispersion (SD) is an effective formulation strategy to improve the dissolution rate of poorly water-soluble compounds.
Dwi, Setyawan, Meivita Yusmala, Dewi, Dewi, Isadiartuti   +2 more
openaire   +2 more sources