Results 161 to 170 of about 2,316 (200)
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Panorama of dissolving microneedles for transdermal drug delivery
Life Sciences, 2021Recently, microfabrication technology has been developed to increase the permeability of drugs for transdermal delivery. Microneedles are ultra-small needles usually in the micron size range (different dimensions in micron), generate pores, and allow for delivery of local medication in the systemic circulation via skin.
Mayuri, Dalvi +5 more
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Slowly dissolving intradermal microneedles
Nature Biomedical Engineering, 2019A patch that deposits an array of microneedle tips under the top layer of the skin enables weeks-long delivery of a contraceptive in rats.
Donnelly, Ryan F., Larraňeta, Eneko
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Dissolvable polymer microneedles for drug delivery and diagnostics
Journal of Controlled Release, 2022Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport a wide selection of active compounds into the skin. To provide an effective therapeutic outcome, μNDs must pierce the human stratum corneum (~10 to 20 μm), without rupturing or bending during penetration, then release their cargo at the predetermined area and time.
Ali, Masood +4 more
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Systemic delivery of artemether by dissolving microneedles
International Journal of Pharmaceutics, 2016Dissolving microneedles (DMNs) based transdermal delivery is an attractive drug delivery approach with minimal invasion. However, it is still challenging to load poorly water-soluble drugs in DMNs for systemic delivery. The aim of the study was to develop DMNs loaded with artemether (ARM) as a model drug, to enable efficient drug penetration through ...
Yuqin, Qiu +5 more
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Dissolvable Microneedles for the Treatment of Rheumatoid Arthritis
Micro and Nanosystems, 2023null Sanshita, Inderbir Singh
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Dissolving microneedles: Safety Considerations and Future Perspectives
Therapeutic Delivery, 2016As the largest and most accessible organ in the body, with a surface area of 1.5–2 m 2 , the skin is an enticing target for drug delivery. Delivery of medication through the skin has expanded beyond the initial brief of topical delivery for local action to the transdermal application of drugs designed for systemic absorption and action.
Quinn, Helen L +2 more
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Dissolving microneedles for cellulitis: a systematic review
Journal of Biomaterials Science, Polymer EditionDissolving microneedles (DMNs) have attracted significant interest due to their superior physicochemical properties, including enhanced skin penetration, improved bioavailability, and reduced toxicity compared to conventional drug delivery systems.
Arya Tripathi +8 more
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Transdermal Insulin Application System with Dissolving Microneedles
Diabetes Technology & Therapeutics, 2012The aim of this report was to develop a dissolving microneedle (DM) application system, where 225-300 insulin-loaded DMs were formed on a chip. After the heat-sealed sheet is removed, the system covered with the press-through package layer is put on the skin.
Yukako, Ito +5 more
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Multiscale simulations of drug distributions in polymer dissolvable microneedles
Colloids and Surfaces B: Biointerfaces, 2020Drug distribution in polymer dissolvable microneedles (MNs) is essential for enhancing the efficiency of drug delivery. In the present work, multiscale simulation was applied to study the interactions between polymer and drug molecules, which may influence the drug distribution in the MNs. In this study, Hyaluronic acid (HA) and Polyvinyl alcohol (PVA)
Yun Hao Feng +4 more
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Fabrication and Evaluation of Glabridin Tip-loaded Dissolving Microneedles
Current Drug Delivery, 2021Background: The clinical application of glabridin in treating skin diseases has been constrained by the limitations of its poor chemical stability and low skin permeability. Objective: Here, we describe Tip-loading Dissolving Microneedles (TDMNs) encapsulating drugs only in the tips of needles for glabridin delivery with improved stability and skin ...
Jianmin Chen +6 more
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