Results 171 to 180 of about 2,316 (200)

Dissolvable Immunomodulatory Microneedles for Treatment of Skin Wounds

Advanced Healthcare Materials
AbstractSustained inflammation can halt or delay wound healing, and macrophages play a central role in wound healing. Inflammatory macrophages are responsible for the removal of pathogens, debris, and neutrophils, while anti‐inflammatory macrophages stimulate various regenerative processes. Recombinant human Proteoglycan 4 (rhPRG4) is shown to modulate
Pejman Ghelich, Mohamadmahdi Samandari, Alireza Hassani Najafabadi, Adam Tanguay, Jacob Quint, Nikhil Menon, Delaram Ghanbariamin, Farnoosh Saeedinejad, Fatemeh Alipanah, Ramaswamy Chidambaram, Roman Krawetz, Kristo Nuutila, Steven Toro, Lindsay Barnum, Gregory D. Jay, Tannin A. Schmidt, Ali Tamayol   +16 more
openaire   +2 more sources

Self-dissolving microneedles for the percutaneous absorption of EPO in mice

Journal of Drug Targeting, 2006
Erythropoietin (EPO) loaded microneedles were prepared using thread-forming polymer as a base for the percutaneous administration of EPO. The used polymers were dextrin, chondroitin sulfate and albumin. Under room temperature, EPO solution was added to high concentration of polymer solution and microneedles were prepared by forming thread with ...
Yukako, Ito, Jun-Ichiro, Yoshimitsu, Keiji, Shiroyama, Nobuyuki, Sugioka, Kanji, Takada   +4 more
openaire   +2 more sources

Dissolving microneedles: Drug delivery and disease treatment

Colloids and Surfaces B: Biointerfaces
Traditional transdermal drug delivery methods are often plagued by technical inefficiencies, limited absorption, and the potential for adverse reactions. In contrast, dissolving microneedles (DMNs) offer a novel approach to transdermal drug delivery by effectively merging the benefits of subcutaneous injection with those of conventional transdermal ...
Yanling Zhuo, Fangyue Wang, Qizhuang Lv, Chunyan Fang   +3 more
openaire   +2 more sources

Dissolving microneedles: standing out in melanoma treatment

Journal of Materials Chemistry B
Melanoma is one of the most significant and dangerous superficial skin tumors with a high fatality rate, thanks to its high invasion rate, drug resistance and frequent metastasis properties.
Jingting Huang, Xihao Wang, Zhengyong Li
openaire   +2 more sources

Dissolving Microneedle Arrays for Transdermal Delivery of Amphiphilic Vaccines

Small, 2017
Amphiphilic vaccine based on lipid‐polymer conjugates is a new type of vaccine capable of self‐delivering to the immune system. When injected subcutaneously, amphiphilic vaccines efficiently target antigen presenting cells in the lymph nodes (LNs) via a unique albumin‐mediated transport and uptake mechanism and induce potent humoral and cellular immune
Myunggi, An, Haipeng, Liu
openaire   +2 more sources

A tearable dissolving microneedle system for shortening application time

Expert Opinion on Drug Delivery, 2019
A tearable dissolving microneedle system (TD-MN system) was developed for shortening the time required to administer drugs into the skin through the dissolving microneedles.TD-MN system consisted of an array of tearable dissolving microneedles (TD-MN) and micro-pillars. The microneedle tips had a female part to integrate with the micro-pillars.
Won-Jun Lee, Mee-Ree Han, Ji-Seok Kim, Jung-Hwan Park   +3 more
openaire   +2 more sources

Dissolving microneedle vaccination—No magic needled

Science Translational Medicine, 2018
Amphiphilic polymeric microneedles dissolve into nanomicelles that inhibit tumor growth.
openaire   +1 more source

Rapidly Dissolvable Microneedle Patches for Transdermal Delivery of Exenatide

Pharmaceutical Research, 2014
To assess the feasibility of transdermal delivery of exenatide (EXT) using low-molecular-weight sodium hyaluronate (HA) dissolving microneedles (MNs) patches for type 2 diabetes mellitus therapy.Micromold casting method was used to fabricate EXT-loaded dissolving MNs.
Zhuangzhi, Zhu, Huafei, Luo, Wangding, Lu, Hansen, Luan, Yubo, Wu, Jing, Luo, Youjie, Wang, Jiaxin, Pi, Chee Yen, Lim, Hao, Wang   +9 more
openaire   +2 more sources

Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate

Expert Opinion on Drug Delivery
Dissolving microneedles (DMNs) have shown great potential for transdermal drug delivery due to their excellent skin-penetrating ability and combination with nanocarriers (NCs) can realize targeted drug delivery. The objective of this study was to investigate the impact of microneedle dissolving rate on the in vivo fate of NC-loaded DMNs, which would ...
Jinghang, Cong, Ziyang, Zheng, Yanping, Fu, Ziyao, Chang, Chuangxin, Chen, Chuanbin, Wu, Xin, Pan, Zhengwei, Huang, Guilan, Quan   +8 more
openaire   +2 more sources

Dissolving microneedles for brain delivery: Recent advances and challenges

Drug Discovery Today
Over the past decade, dissolving microneedles (DMNs) have emerged as a promising approach for drug delivery to the brain. They are tiny devices designed to penetrate biological barriers, offering a painless method for localized and controlled drug delivery. They are suitable for delivering drugs that are susceptible to degradation when delivered orally.
Kaustubh Ajit, Kolekar, Popat S, Kumbhar, Sukriti, Vishwas, Kamal, Dua, Sachin Kumar, Singh   +4 more
openaire   +2 more sources